Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 15/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.34 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17356895 | 0.85 | HDAC6 (0.38) | HDAC6HDAC1HDAC8HDAC2HDAC3 | |
| SCHEMBL9568939 | 0.71 | CHRNB2 (0.37) | MEN1ALDH1A1KMT2AADORA1 | |
| SCHEMBL17356908 | 0.70 | HDAC6 (0.41) | HDAC6HDAC1HDAC8HDAC2HDAC3 | |
| SCHEMBL17621736 | 0.69 | CHRNB2 (0.35) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL10841771 | 0.67 | ALDH1A1 (0.40) | MEN1ALDH1A1KMT2AADORA1CHRM2 | |
| SCHEMBL8322143 | 0.65 | — | — | |
| Oxalic Acid SCHEMBL9404378 | 0.63 | CHRM5 (0.46) | ALDH1A1LMNACHRM2CHRM4CHRM5 | |
| SCHEMBL21514732 | 0.63 | — | — | |
| SCHEMBL19099706 | 0.63 | HDAC6 (0.48) | HDAC6HDAC1HDAC8HDAC2HDAC3 | |
| SCHEMBL15824729 | 0.63 | CHRM2 (0.64) | HDAC6HDAC1HDAC8HDAC2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180215726-A1 | CYCLOALKENYL HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS | THE BROAD INSTITUTE, INC. (US) | 2018-08-02 | — | — | US | disclosed |
| US-9914717-B2 | Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors | THE BROAD INSTITUTE, INC. (US) | 2018-03-13 | — | — | US | disclosed |
| US-20150368221-A1 | CYCLOALKENYL HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS | THE BROAD INSTITUTE, INC. | 2015-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180215726-A1 | CYCLOALKENYL HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC3, HDAC7 | HDAC6 9/4885HDAC1 1/4885MEN1 4238/4885 |
| US-20150368221-A1 | CYCLOALKENYL HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC3, HDAC7 | HDAC6 10/4885HDAC1 1/4885MEN1 4260/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.