Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | SELL | P14151 | 1/20 | 0.39 |
| ▸ | SELP | P16109 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | FASN | P49327 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19763340 | 0.89 | HDAC1 (0.76) | HDAC1ALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL19003405 | 0.87 | HDAC1 (0.53) | HDAC1ALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL26441808 | 0.84 | HDAC1 (0.54) | HDAC1ALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL26441880 | 0.80 | HDAC1 (0.58) | HDAC1ALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL26441706 | 0.78 | HDAC1 (0.70) | HDAC1ALDH1A1HPGDKDM4EMAPT | |
| Exifone SCHEMBL273096 | 0.75 | HDAC1 (1.00) | HDAC1ALDH1A1HPGDKDM4EMAPT | |
| Exifone SCHEMBL29375026 | 0.75 | HDAC1 (1.00) | HDAC1ALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL38623 | 0.74 | SELL (0.64) | ALDH1A1HPGDKDM4EMAPTALOX15 | |
| SCHEMBL6847401 | 0.74 | HDAC1 (0.84) | HDAC1ALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL12672384 | 0.74 | SELL (0.46) | HDAC1ALDH1A1HPGDKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150368300-A1 | COMPOSITIONS AND METHODS RELATING TO HINDERING DOT1L RECRUITMENT BY MLL-FUSION PROTEINS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2015-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150368300-A1 | COMPOSITIONS AND METHODS RELATING TO HINDERING DOT1L RECRUITMENT BY MLL-FUSION PROTEINS | MLLT3, MLLT1, DOT1L | HDAC1 253/4885ALDH1A1 4036/4885HPGD 4501/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.