Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | SLC9A3 | P48764 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.43 |
| ▸ | KLK7 | P49862 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16785946 | 0.84 | PDE4A (0.42) | PDE4ASLC9A3MEN1KMT2AKLK7 | |
| SCHEMBL17364325 | 0.84 | KMT2A (0.44) | PDE4AMEN1KMT2ANPC1GAA | |
| SCHEMBL8058913 | 0.84 | PDE4A (0.48) | PDE4ASLC9A3MEN1KMT2ANPC1 | |
| SCHEMBL29051509 | 0.83 | PDE4A (0.44) | PDE4AMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL30498890 | 0.83 | PDE4A (0.44) | PDE4AMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL18872551 | 0.82 | PDE4A (0.40) | PDE4ASLC9A3MEN1KMT2ALMNA | |
| SCHEMBL11114702 | 0.82 | KMT2A (0.55) | MEN1KMT2ANPC1KLK7ALDH1A1 | |
| SCHEMBL16788260 | 0.82 | KMT2A (0.55) | MEN1KMT2ANPC1KLK7ALDH1A1 | |
| SCHEMBL9614867 | 0.81 | NPC1 (0.57) | PDE4AMEN1KMT2ANPC1GAA | |
| SCHEMBL7196074 | 0.81 | MAPT (0.48) | PDE4AMEN1KMT2ANPC1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10004222-B2 | Small molecule ice recrystallization inhibitors and methods of use thereof | THE UNIVERSITY OF OTTAWA (CA) | 2018-06-26 | — | — | US | claimed |
| US-20150373968-A1 | Small Molecule Ice Recrystallization Inhibitors And Methods Of Use Thereof | THE UNIVERSITY OF OTTAWA (CA) | 2015-12-31 | — | — | US | claimed |
| US-20240268372-A1 | Methods and Compositions for Extending Organ and Tissue Preservation | MASSACHUSETTS GEN HOSPITAL (US) | 2024-08-15 | — | — | US | disclosed |
| WO-2022241417-A1 | METHODS AND COMPOSITIONS FOR EXTENDING ORGAN AND TISSUE PRESERVATION | THE GENERAL HOSPITAL CORPORATION (US) | 2022-11-17 | — | — | WO | disclosed |
| US-10004222-B2 | Small molecule ice recrystallization inhibitors and methods of use thereof | THE UNIVERSITY OF OTTAWA (CA) | 2018-06-26 | — | — | US | disclosed |
| US-10004222-B2 | Small molecule ice recrystallization inhibitors and methods of use thereof | THE UNIVERSITY OF OTTAWA (CA) | 2018-06-26 | — | — | US | disclosed |
| US-20150373968-A1 | Small Molecule Ice Recrystallization Inhibitors And Methods Of Use Thereof | THE UNIVERSITY OF OTTAWA (CA) | 2015-12-31 | — | — | US | disclosed |
| US-20150373968-A1 | Small Molecule Ice Recrystallization Inhibitors And Methods Of Use Thereof | THE UNIVERSITY OF OTTAWA (CA) | 2015-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10004222-B2 | Small molecule ice recrystallization inhibitors and methods of use thereof | MCL1, IDH3B, IDH3A | PDE4A 4090/4885SLC9A3 3046/4885MEN1 4758/4885 |
| US-20150373968-A1 | Small Molecule Ice Recrystallization Inhibitors And Methods Of Use Thereof | MCL1, DCX, IDH3B | PDE4A 3718/4885SLC9A3 3257/4885MEN1 4851/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.