Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 4/20 | 0.55 |
| ▸ | THRA | P10827 | 3/20 | 0.55 |
| ▸ | PPARG | P37231 | 3/20 | 0.55 |
| ▸ | RXRA | P19793 | 2/20 | 0.55 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.55 |
| ▸ | ITGAV | P06756 | 1/20 | 0.55 |
| ▸ | PCNA | P12004 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TTR | P02766 | 2/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.47 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14239795 | 0.96 | THRB (0.50) | THRBTHRAPPARGRXRAITGB3 | |
| SCHEMBL1526151 | 0.95 | THRB (0.60) | THRBTHRAPPARGRXRAITGB3 | |
| SCHEMBL12837226 | 0.93 | THRB (0.52) | THRBTHRAPPARGRXRAITGB3 | |
| SCHEMBL12837227 | 0.83 | THRB (0.46) | THRBTHRAPPARGRXRAITGB3 | |
| SCHEMBL16124428 | 0.83 | PCNA (0.67) | THRBTHRAPPARGRXRAPCNA | |
| SCHEMBL1526155 | 0.82 | EPHX2 (0.44) | THRBTHRAPPARGRXRAITGB3 | |
| SCHEMBL12837224 | 0.82 | EPHX2 (0.43) | THRBTHRAPPARGRXRAITGB3 | |
| SCHEMBL1525943 | 0.82 | EPHX2 (0.42) | THRBTHRAPPARGRXRAITGB3 | |
| SCHEMBL12837222 | 0.81 | EPHX2 (0.42) | THRBTHRAPPARGRXRAITGB3 | |
| SCHEMBL12837302 | 0.78 | THRB (0.89) | THRBTHRAPPARGRXRAITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2442800-B1 | NANOPARTICLE AND POLYMER FORMULATIONS FOR THYROID HORMONE, ANALOGS, ANTAGONISTS, AND FORMULATIONS AND USES THEREOF | NANOPHARMACEUTICALS LLC (US) | 2019-04-24 | — | — | EP | disclosed |
| US-9220788-B2 | Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists, and formulations and uses thereof | NANOPHARMACEUTICALS LLC (US) | 2015-12-29 | — | — | US | disclosed |