Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 5/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30121977 | 0.93 | MDM2 (0.64) | MDM2TP53MAPTALDH1A1GAA | |
| SCHEMBL17366151 | 0.87 | MDM2 (0.58) | MDM2TP53MAPTALDH1A1GAA | |
| SCHEMBL17366174 | 0.87 | MDM2 (0.58) | MDM2TP53MAPTALDH1A1GAA | |
| SCHEMBL17366155 | 0.84 | CYP2C9 (0.56) | MDM2MAPTCA12CA1CA9 | |
| SCHEMBL17366179 | 0.84 | MDM2 (0.55) | MDM2TP53MAPTCASP3ALDH1A1 | |
| SCHEMBL17366170 | 0.84 | MDM2 (0.64) | MDM2TP53MAPTALDH1A1GAA | |
| SCHEMBL17366150 | 0.84 | MDM2 (0.55) | MDM2TP53ALDH1A1GAAHTT | |
| SCHEMBL17366148 | 0.83 | CYP2C9 (0.57) | MDM2TP53CA12CA1CA9 | |
| SCHEMBL17366156 | 0.83 | MDM2 (0.60) | MDM2TP53MAPTALDH1A1GAA | |
| SCHEMBL17366172 | 0.80 | MDM2 (0.54) | MDM2TP53MAPTALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2960233-B1 | NEW THERAPEUTIC AGENTS | CANCER RESEARCH TECH LTD (GB) | 2019-10-30 | — | — | EP | disclosed |
| EP-2960233-A1 | NEW THERAPEUTIC AGENTS | Cancer Research Technology Limited (GB) | 2015-12-30 | — | — | EP | disclosed |