Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.56 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.48 |
| ▸ | CDK2 | P24941 | 4/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.48 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.48 |
| ▸ | CCNK | O75909 | 2/20 | 0.47 |
| ▸ | CCND3 | P30281 | 2/20 | 0.47 |
| ▸ | CDK9 | P50750 | 2/20 | 0.47 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6206101 | 0.83 | TSHR (0.68) | HTTTSHRNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10939229 | 0.82 | TSHR (0.67) | HTTLRRK2TSHRNPC1RAB9A | |
| SCHEMBL6489892 | 0.81 | RAPGEF4 (0.49) | HTTNPC1RAB9AKMT2AKDM4E | |
| SCHEMBL13395050 | 0.80 | AURKA (0.47) | HTTCDK2CDK5CDK9TSHR | |
| SCHEMBL9818543 | 0.80 | HTT (0.67) | HTTLRRK2CCNA2CDK2CDK5 | |
| SCHEMBL2493802 | 0.80 | HTT (1.00) | HTTLRRK2CCNA2CDK2CDK5 | |
| SCHEMBL6482620 | 0.79 | ULK1 (0.49) | HTTTSHRNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10151119 | 0.78 | HTT (0.41) | HTTLRRK2TSHRNPC1RAB9A | |
| SCHEMBL13395229 | 0.77 | ALK (0.55) | HTTCDK9TSHRNPC1RAB9A | |
| SCHEMBL16803641 | 0.77 | ALK (0.48) | CDK9PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2704572-B1 | COMPOUNDS FOR INHIBITING CELL PROLIFERATION IN EGFR-DRIVEN CANCERS | ARIAD PHARMA INC (US) | 2015-12-30 | — | — | EP | disclosed |