Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 4/20 | 0.64 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.64 |
| ▸ | TPX2 | Q9ULW0 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | ENPP3 | O14638 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | ULK1 | O75385 | 1/20 | 0.47 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.47 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL581165 | 0.86 | AURKA (0.69) | AURKAAURKBTPX2ULK1RPS6KA5 | |
| SCHEMBL580954 | 0.85 | AURKA (0.62) | AURKAAURKBTPX2MAPTLMNA | |
| SCHEMBL580535 | 0.84 | AURKA (0.59) | AURKAAURKBTPX2MAPTLMNA | |
| SCHEMBL581561 | 0.81 | AURKA (0.56) | AURKAAURKBTPX2MAPTLMNA | |
| SCHEMBL581258 | 0.81 | AURKA (0.71) | AURKAAURKBTPX2MAPTLMNA | |
| SCHEMBL12315947 | 0.81 | AURKA (0.64) | AURKAAURKBTPX2MAPTLMNA | |
| SCHEMBL581146 | 0.81 | AURKA (0.65) | AURKAAURKBTPX2ULK1RPS6KA5 | |
| SCHEMBL580541 | 0.80 | AURKA (0.77) | AURKAAURKBTPX2MAPTLMNA | |
| SCHEMBL580405 | 0.80 | AURKA (0.77) | AURKAAURKBTPX2MAPTLMNA | |
| SCHEMBL580476 | 0.80 | AURKA (0.64) | AURKAAURKBTPX2MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984353-B1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC (US) | 2015-12-30 | — | — | EP | disclosed |