Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.59 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.59 |
| ▸ | TPX2 | Q9ULW0 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | ENPP3 | O14638 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL581165 | 0.88 | AURKA (0.69) | AURKAAURKBTPX2 | |
| SCHEMBL581019 | 0.85 | AURKA (0.58) | AURKAAURKBTPX2MAPTLMNA | |
| SCHEMBL15809924 | 0.84 | AURKA (0.52) | AURKAAURKBTPX2MAPTLMNA | |
| SCHEMBL17366294 | 0.84 | AURKA (0.64) | AURKAAURKBTPX2MAPTLMNA | |
| SCHEMBL581677 | 0.83 | AURKA (0.55) | AURKAAURKBTPX2MAPTLMNA | |
| SCHEMBL581258 | 0.81 | AURKA (0.71) | AURKAAURKBTPX2MAPTLMNA | |
| SCHEMBL580954 | 0.81 | AURKA (0.62) | AURKAAURKBTPX2MAPTLMNA | |
| SCHEMBL581561 | 0.79 | AURKA (0.56) | AURKAAURKBTPX2MAPTLMNA | |
| SCHEMBL580566 | 0.79 | AURKA (0.52) | AURKAAURKBTPX2MAPTLMNA | |
| SCHEMBL580548 | 0.79 | AURKA (0.51) | AURKAAURKBTPX2MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984353-B1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC (US) | 2015-12-30 | — | — | EP | disclosed |
| EP-2418209-B1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC (US) | 2014-06-25 | — | — | EP | disclosed |
| EP-2418209-A1 | Aurora kinase modulators and method of use | Amgen Inc. (US) | 2012-02-15 | — | — | EP | disclosed |