Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 15/20 | 0.45 |
| ▸ | CNR2 | P34972 | 4/20 | 0.41 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL174454 | 0.88 | CNR2 (0.38) | DGAT1CNR2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL162108 | 0.85 | DGAT1 (0.45) | DGAT1SOAT1CYP2C19 | |
| SCHEMBL164578 | 0.79 | DGAT1 (0.58) | DGAT1CNR1 | |
| SCHEMBL174323 | 0.77 | DGAT1 (0.57) | DGAT1CNR1 | |
| SCHEMBL161999 | 0.76 | DGAT1 (0.58) | DGAT1 | |
| SCHEMBL163439 | 0.76 | DGAT1 (0.55) | DGAT1SOAT1CNR1 | |
| SCHEMBL162202 | 0.75 | DGAT1 (0.57) | DGAT1SOAT1 | |
| SCHEMBL162749 | 0.75 | DGAT1 (0.46) | DGAT1SOAT1CNR1 | |
| SCHEMBL165064 | 0.73 | DGAT1 (0.57) | DGAT1CNR1 | |
| SCHEMBL159062 | 0.73 | DGAT1 (0.47) | DGAT1SOAT1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611783-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | Piramal Enterprises Limited (IN) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012029032-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2012-03-08 | — | — | WO | disclosed |