Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 5/20 | 0.38 |
| ▸ | DHODH | Q02127 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL173668 | 0.88 | DGAT1 (0.45) | CNR2CYP2D6CYP2C9CYP2C19DGAT1 | |
| SCHEMBL174183 | 0.81 | SMN1; SMN2 (0.41) | MEN1KMT2AALDH1A1GAAJAK2 | |
| SCHEMBL161358 | 0.78 | DGAT1 (0.52) | DGAT1MAPTSMN1; SMN2KDR | |
| SCHEMBL161469 | 0.78 | DGAT1 (0.49) | DHODHMEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL161945 | 0.78 | DGAT1 (0.51) | DHODHMEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL163102 | 0.77 | L3MBTL1 (0.42) | DHODHMEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL162246 | 0.76 | DGAT1 (0.41) | DHODHMEN1KMT2AL3MBTL1JAK2 | |
| SCHEMBL173905 | 0.76 | DGAT1 (0.52) | ALDH1A1GAAJAK2JAK1TYK2 | |
| SCHEMBL160518 | 0.75 | DGAT1 (0.42) | MEN1KMT2AL3MBTL1ALDH1A1GAA | |
| SCHEMBL163875 | 0.75 | DGAT1 (0.44) | MEN1KMT2AL3MBTL1JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611783-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | Piramal Enterprises Limited (IN) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012029032-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2012-03-08 | — | — | WO | disclosed |