Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 3/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 6/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15915443 | 0.85 | ALDH1A1 (0.62) | KDM4EALDH1A1HTR6PKMCYP3A4 | |
| SCHEMBL3087652 | 0.83 | POLB (0.59) | KDM4EALDH1A1KMT2AHTR6CYP3A4 | |
| SCHEMBL15917589 | 0.82 | GAA (0.59) | KDM4EALDH1A1KMT2A | |
| SCHEMBL15914906 | 0.80 | ALDH1A1 (0.52) | KDM4EALDH1A1MEN1KMT2APKM | |
| SCHEMBL10724375 | 0.78 | POLB (0.67) | MEN1KMT2ADRD2HTR6PKM | |
| SCHEMBL29973515 | 0.77 | TSHR (0.66) | KDM4EALDH1A1MEN1KMT2ACYP3A4 | |
| SCHEMBL15917236 | 0.77 | TSHR (0.71) | KDM4EALDH1A1MEN1KMT2ACYP3A4 | |
| SCHEMBL15916530 | 0.76 | TSHR (0.75) | ALDH1A1MEN1KMT2ACYP3A4 | |
| SCHEMBL15916754 | 0.76 | TSHR (0.75) | ALDH1A1MEN1KMT2ACYP3A4 | |
| SCHEMBL16733908 | 0.76 | ALDH1A1 (0.61) | ALDH1A1MEN1KMT2APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9745328-B2 | Flap modulators | JANSSEN PHARMACEUTICA NV (BE) | 2017-08-29 | — | — | US | disclosed |
| US-20150376212-A1 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150376212-A1 | FLAP MODULATORS | FEN1, PGF, TBXA2R | KDM4E 1984/4885ALDH1A1 200/4885MEN1 1999/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.