Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | CA6 | P23280 | 1/20 | 0.46 |
| ▸ | EDNRA | P25101 | 2/20 | 0.42 |
| ▸ | EDNRB | P24530 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15915326 | 0.91 | POLB (0.50) | RECQLPOLBTDP1MAPTPLCG1 | |
| SCHEMBL15916636 | 0.91 | POLB (0.50) | RECQLPOLBTDP1MAPTPLCG1 | |
| SCHEMBL15916634 | 0.91 | POLB (0.50) | RECQLPOLBTDP1MAPTPLCG1 | |
| SCHEMBL17310031 | 0.80 | MAPT (0.53) | RECQLPOLBTDP1MAPTPLCG1 | |
| SCHEMBL3057056 | 0.79 | NR3C1 (0.40) | TDP1NR3C1PGRNR3C2 | |
| SCHEMBL15915696 | 0.79 | POLB (0.48) | RECQLPOLBTDP1MAPTPLCG1 | |
| SCHEMBL15915697 | 0.79 | POLB (0.48) | RECQLPOLBTDP1MAPTPLCG1 | |
| SCHEMBL17085024 | 0.77 | POLB (0.47) | RECQLPOLBTDP1MAPTPLCG1 | |
| SCHEMBL3189244 | 0.77 | ALOX5AP (0.48) | RECQLPOLBTDP1MAPTPLCG1 | |
| SCHEMBL15915406 | 0.77 | POLB (0.52) | RECQLPOLBPLCG1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9745328-B2 | Flap modulators | JANSSEN PHARMACEUTICA NV (BE) | 2017-08-29 | — | — | US | disclosed |
| US-20150376212-A1 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150376212-A1 | FLAP MODULATORS | FEN1, PGF, TBXA2R | RECQL 162/4885POLB 1439/4885TDP1 355/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.