SCHEMBL17372802

SCHEMBL17372802

COC(=O)Oc1cc(I)cnc1Cl

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CUL4A Q13619 2/20 0.37
KDM4E B2RXH2 4/20 0.36
HPGD P15428 2/20 0.36
HSD17B10 Q99714 1/20 0.36
MAPT P10636 3/20 0.34
ALDH1A1 P00352 2/20 0.34
HTT P42858 2/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
JAK2 O60674 1/20 0.34
GAA P10253 1/20 0.34
CNR2 P34972 1/20 0.33
STAT3 P40763 2/20 0.32
NPSR1 Q6W5P4 1/20 0.32
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
POLB P06746 1/20 0.32
MAPK1 P28482 1/20 0.32
LMNA P02545 1/20 0.32
PIK3CG P48736 1/20 0.32
OPRK1 P41145 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17372805 0.77 EGLN1 (0.38) CUL4AKDM4EHPGDHSD17B10MAPT
SCHEMBL1505507 0.73 OPRK1 (0.46) KDM4EALDH1A1GAAOPRK1GLA
SCHEMBL11112054 0.70 CUL4A (0.44) CUL4AKDM4EHPGDHSD17B10MAPT
SCHEMBL23976367 0.69 PIK3CD (0.33) MAPTSMN1; SMN2GAA
SCHEMBL26667036 0.68 MAPT (0.47) KDM4EHPGDHSD17B10MAPTALDH1A1
SCHEMBL26667021 0.68 MAPT (0.46) KDM4EHPGDHSD17B10MAPTALDH1A1
SCHEMBL30911731 0.68 SLC2A1 (0.36)
SCHEMBL26667044 0.67 TPMT (0.40) CUL4AKDM4EHPGDHSD17B10MAPT
SCHEMBL21596479 0.67 CA12 (0.41) KDM4EHPGDHSD17B10MAPTALDH1A1
SCHEMBL10751222 0.66 LMNA (0.55) CUL4AKDM4EHPGDHSD17B10MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3169674-B1 ARYL-TRIAZOLYL-PYRIDINES AS PESTICIDES BAYER ANIMAL HEALTH GMBH (DE) 2021-01-20 EP disclosed
EP-3157913-B1 PYRAZOLYL TRIAZOLYL PYRIDINES AS PESTICIDE BAYER ANIMAL HEALTH GMBH (DE) 2019-04-17 EP disclosed
EP-3169674-A1 ARYL-TRIAZOLYL PYRIDINES AS PEST CONTROL AGENTS Bayer Animal Health GmbH (DE) 2017-05-24 EP disclosed
EP-3157913-A1 PYRAZOLYL-TRIAZOLYL-PYRIDINES AS PEST-CONTROL AGENTS Bayer Animal Health GmbH (DE) 2017-04-26 EP disclosed
WO-2016008830-A1 ARYL-TRIAZOLYL PYRIDINES AS PEST CONTROL AGENTS BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2016-01-21 WO disclosed
WO-2015193216-A1 PYRAZOLYL-TRIAZOLYL-PYRIDINES AS PEST-CONTROL AGENTS BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2015-12-23 WO disclosed