Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 5/20 | 0.51 |
| ▸ | AHR | P35869 | 2/20 | 0.49 |
| ▸ | TTK | P33981 | 1/20 | 0.47 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.47 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.46 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.46 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.46 |
| ▸ | PRKCI | P41743 | 1/20 | 0.45 |
| ▸ | TDP2 | O95551 | 1/20 | 0.44 |
| ▸ | ERN1 | O75460 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | PRF1 | P14222 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27660734 | 0.78 | MKNK1 (0.48) | AHR | |
| SCHEMBL31422694 | 0.76 | PARP1 (0.64) | PARP1TDP2ERN1 | |
| SCHEMBL2431097 | 0.76 | PARP1 (0.64) | PARP1TDP2ERN1 | |
| SCHEMBL4080073 | 0.76 | CSNK2A1 (0.49) | PARP1TTKMAP2K4BAZ2BBAZ2A | |
| SCHEMBL4078164 | 0.76 | ERN1 (0.49) | PARP1TTKMAP2K4PDK2BAZ2B | |
| SCHEMBL27671398 | 0.75 | AHR (0.55) | AHRPDK2 | |
| SCHEMBL6999225 | 0.74 | DHODH (0.63) | PARP1TDP2ERN1 | |
| SCHEMBL5479593 | 0.74 | PARP1 (0.78) | PARP1TTKMAP2K4ERN1 | |
| SCHEMBL5307077 | 0.74 | PARP1 (0.56) | PARP1PDK2BAZ2BBAZ2APRKCI | |
| SCHEMBL18618316 | 0.74 | PARP1 (0.47) | PARP1TTKMAP2K4BAZ2BBAZ2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3157902-A1 | NEW SULFONYLAMINOBENZAMIDE COMPOUNDS | Novartis Tiergesundheit AG (CH) | 2017-04-26 | — | — | EP | disclosed |
| WO-2015195423-A1 | NEW SULFONYLAMINOBENZAMIDE COMPOUNDS | NOVARTIS TIERGESUNDHEIT AG (CH) | 2015-12-23 | — | — | WO | disclosed |
| CN-101849953-B | Inflammatory cytokine release inhibitor | INST MED MOLECULAR DESIGN INC | 2012-04-25 | — | — | CN | disclosed |
| CN-101849953-A | Inflammatory cytokine release inhibitor | INST MED MOLECULAR DESIGN INC | 2010-10-06 | — | — | CN | disclosed |
| CN-100370975-C | Inflammatory cytokine production dissociation inhibitor | INST OF MEDICINE MOLECULAR DES (JP) | 2008-02-27 | — | — | CN | disclosed |
| CN-101125138-A | Inhibitors against the production and release of inflammatory cytokines | INST MED MOLECULAR DESIGN INC (JP) | 2008-02-20 | — | — | CN | disclosed |
| CN-1489458-A | Inflammatory cytokine production dissociation inhibitor | ��ʽ����ҽҩ��������о��� | 2004-04-14 | — | — | CN | disclosed |