Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STIM1 | Q13586 | 3/20 | 0.38 |
| ▸ | ORAI1 | Q96D31 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.36 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17380992 | 0.96 | NPC1 (0.36) | STIM1ORAI1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17375151 | 0.92 | STIM1 (0.45) | STIM1ORAI1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17375222 | 0.91 | SMN1; SMN2 (0.49) | STIM1ORAI1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17380999 | 0.89 | HTT (0.35) | STIM1ORAI1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17375097 | 0.89 | TRPV4 (0.38) | STIM1ORAI1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17375186 | 0.88 | LCK (0.38) | GRM5HTTHSD17B10 | |
| SCHEMBL17381159 | 0.88 | HSD17B10 (0.47) | NPC1RAB9ASMN1; SMN2GRM5HTT | |
| SCHEMBL17375131 | 0.88 | STIM1 (0.41) | STIM1ORAI1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17375195 | 0.87 | LMNA (0.39) | NPC1RAB9ASMN1; SMN2HTTHSD17B10 | |
| SCHEMBL17381256 | 0.86 | TRPV1 (0.42) | NPC1RAB9ASMN1; SMN2GRM5HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015197188-A1 | PYRAZOLYL-BASED CARBOXAMIDES AS CRAC INHIBITORS | Grünenthal GmbH (DE) | 2015-12-30 | — | — | WO | claimed |
| WO-2015197188-A1 | PYRAZOLYL-BASED CARBOXAMIDES AS CRAC INHIBITORS | Grünenthal GmbH (DE) | 2015-12-30 | — | — | WO | disclosed |
| WO-2015197188-A1 | PYRAZOLYL-BASED CARBOXAMIDES AS CRAC INHIBITORS | Grünenthal GmbH (DE) | 2015-12-30 | — | — | WO | disclosed |