Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | COMT | P21964 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | GABRG2 | P18507 | 11/20 | 0.48 |
| ▸ | GABRB3 | P28472 | 11/20 | 0.48 |
| ▸ | GABRA3 | P34903 | 11/20 | 0.48 |
| ▸ | GABRA2 | P47869 | 11/20 | 0.48 |
| ▸ | GABRA1 | P14867 | 10/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1420047 | 0.73 | MEN1 (0.59) | COMTMEN1KMT2ABACE1KDM4E | |
| SCHEMBL23087750 | 0.67 | HTR2A (0.50) | MEN1KMT2ABACE1KDM4EMAPT | |
| SCHEMBL1420162 | 0.67 | KDM4E (0.61) | COMTMEN1KMT2ABACE1KDM4E | |
| SCHEMBL12324338 | 0.66 | HTR7 (0.48) | COMTMEN1KMT2AGABRG2GABRB3 | |
| SCHEMBL9726036 | 0.66 | MEN1 (0.50) | COMTMEN1KMT2ABACE1KDM4E | |
| SCHEMBL2588840 | 0.65 | ESRRA (0.62) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL15264119 | 0.65 | BRD4 (0.51) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL15707630 | 0.64 | DRD1 (0.60) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL10569299 | 0.63 | ALDH1A1 (0.51) | MEN1KMT2ABACE1KDM4EALDH1A1 | |
| SCHEMBL22721784 | 0.63 | GSTP1 (0.70) | MEN1KMT2ABACE1KDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11028066-B2 | Inhibitors of lysine specific demethylase-1 | CELGENE QUANTICEL RESEARCH, INC. (US) | 2021-06-08 | — | — | US | disclosed |
| US-11028066-B2 | Inhibitors of lysine specific demethylase-1 | CELGENE QUANTICEL RESEARCH, INC. (US) | 2021-06-08 | — | — | US | disclosed |
| CN-106660987-B | Inhibitors of lysine-specific demethylase-1 | 赛尔基因昆蒂赛尔研究公司 | 2020-11-06 | — | — | CN | disclosed |
| US-20200172506-A1 | INHIBITORS OF LYSINE SPECIFIC DEMETHYLASE-1 | CELGENE QUANTICEL RESEARCH, INC. (US) | 2020-06-04 | — | — | US | disclosed |
| US-20200172506-A1 | INHIBITORS OF LYSINE SPECIFIC DEMETHYLASE-1 | CELGENE QUANTICEL RESEARCH, INC. (US) | 2020-06-04 | — | — | US | disclosed |
| EP-3160956-B1 | INHIBITORS OF LYSINE SPECIFIC DEMETHYLASE-1 | CELGENE QUANTICEL RES INC (US) | 2020-05-27 | — | — | EP | disclosed |
| EP-3160956-B1 | INHIBITORS OF LYSINE SPECIFIC DEMETHYLASE-1 | CELGENE QUANTICEL RES INC (US) | 2020-05-27 | — | — | EP | disclosed |
| US-10597376-B2 | Inhibitors of lysine specific demethylase-1 | CELGENE QUANTICEL RESEARCH, INC. (US) | 2020-03-24 | — | — | US | disclosed |
| US-10597376-B2 | Inhibitors of lysine specific demethylase-1 | CELGENE QUANTICEL RESEARCH, INC. (US) | 2020-03-24 | — | — | US | disclosed |
| US-20180273505-A1 | INHIBITORS OF LYSINE SPECIFIC DEMETHYLASE-1 | CELGENE QUANTICEL RESEARCH, INC. (US) | 2018-09-27 | — | — | US | disclosed |
| US-10011583-B2 | Inhibitors of lysine specific demethylase-1 | CELGENE QUANTICEL RESEARCH, INC. (US) | 2018-07-03 | — | — | US | disclosed |
| US-10011583-B2 | Inhibitors of lysine specific demethylase-1 | CELGENE QUANTICEL RESEARCH, INC. (US) | 2018-07-03 | — | — | US | disclosed |
| US-10011583-B2 | Inhibitors of lysine specific demethylase-1 | CELGENE QUANTICEL RESEARCH, INC. (US) | 2018-07-03 | — | — | US | disclosed |
| US-20170137402-A1 | INHIBITORS OF LYSINE SPECIFIC DEMETHYLASE-1 | Quanticel Pharmaceuticals, Inc. | 2017-05-18 | — | — | US | disclosed |
| US-20170137402-A1 | INHIBITORS OF LYSINE SPECIFIC DEMETHYLASE-1 | Quanticel Pharmaceuticals, Inc. | 2017-05-18 | — | — | US | disclosed |
| US-20170137402-A1 | INHIBITORS OF LYSINE SPECIFIC DEMETHYLASE-1 | Quanticel Pharmaceuticals, Inc. | 2017-05-18 | — | — | US | disclosed |
| EP-3160956-A1 | INHIBITORS OF LYSINE SPECIFIC DEMETHYLASE-1 | Celgene Quanticel Research, Inc. (US) | 2017-05-03 | — | — | EP | disclosed |
| WO-2015200843-A1 | INHIBITORS OF LYSINE SPECIFIC DEMETHYLASE-1 | Quanticel Pharmaceuticals, Inc. (US) | 2015-12-30 | — | — | WO | disclosed |
| WO-2015200843-A1 | INHIBITORS OF LYSINE SPECIFIC DEMETHYLASE-1 | Quanticel Pharmaceuticals, Inc. (US) | 2015-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10597376-B2 | Inhibitors of lysine specific demethylase-1 | KDM1B, KDM1A, KDM3A | COMT 440/4885MEN1 1972/4885KMT2A 38/4885 |
| US-11028066-B2 | Inhibitors of lysine specific demethylase-1 | KDM1B, KDM1A, KDM3A | COMT 440/4885MEN1 1972/4885KMT2A 38/4885 |
| US-20170137402-A1 | INHIBITORS OF LYSINE SPECIFIC DEMETHYLASE-1 | KDM1B, KDM1A, KDM3A | COMT 436/4885MEN1 1844/4885KMT2A 36/4885 |
| US-20200172506-A1 | INHIBITORS OF LYSINE SPECIFIC DEMETHYLASE-1 | KDM1B, KDM1A, KDM3A | COMT 440/4885MEN1 1972/4885KMT2A 38/4885 |
| US-10011583-B2 | Inhibitors of lysine specific demethylase-1 | KDM1B, KDM1A, KDM3A | COMT 440/4885MEN1 1972/4885KMT2A 38/4885 |
| US-20180273505-A1 | INHIBITORS OF LYSINE SPECIFIC DEMETHYLASE-1 | KDM1B, KDM1A, KDM3A | COMT 440/4885MEN1 1972/4885KMT2A 38/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.