Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | TNF | P01375 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MMP12 | P39900 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MDM4 | O15151 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MMP9 | P14780 | 2/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | SLC17A5 | Q9NRA2 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16131612 | 0.91 | TNF (0.54) | LMNAKMT2ATNFALDH1A1TSHR | |
| SCHEMBL8618364 | 0.91 | TNF (0.54) | LMNAKMT2ATNFALDH1A1TSHR | |
| SCHEMBL4781575 | 0.91 | TNF (0.54) | LMNAKMT2ATNFALDH1A1TSHR | |
| SCHEMBL14734331 | 0.91 | TNF (0.54) | LMNAKMT2ATNFALDH1A1TSHR | |
| SCHEMBL14402250 | 0.89 | LMNA (0.49) | LMNAKMT2APOLBTNFALDH1A1 | |
| SCHEMBL14402300 | 0.89 | LMNA (0.49) | LMNAKMT2APOLBTNFALDH1A1 | |
| SCHEMBL15976238 | 0.89 | LMNA (0.49) | LMNAKMT2APOLBTNFALDH1A1 | |
| SCHEMBL17969701 | 0.89 | LMNA (0.49) | LMNAKMT2APOLBTNFALDH1A1 | |
| SCHEMBL12838274 | 0.89 | LMNA (0.49) | LMNAKMT2APOLBTNFALDH1A1 | |
| SCHEMBL17969698 | 0.89 | LMNA (0.49) | LMNAKMT2APOLBTNFALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858538-B1 | MUCIN HYPERSECRETION INHIBITORS BASED ON THE STRUCTURE OF MANS AND METHODS OF USE | BIOMARCK PHARMACEUTICALS LTD (US) | 2019-03-27 | — | — | EP | disclosed |
| US-9598463-B2 | Mucin hypersecretion inhibitors and methods of use | BIOMARCK PHARMACEUTICALS, LTD. (US) | 2017-03-21 | — | — | US | disclosed |
| US-20150274778-A1 | MUCIN HYPERSECRETION INHIBITORS AND METHODS OF USE | BIOMARCK PHARMACEUTICALS, LTD. | 2015-10-01 | — | — | US | disclosed |
| US-8907056-B2 | Mucin hypersecretion inhibitors and methods of use | BIOMARCK PHARMACEUTICALS, LTD. (US) | 2014-12-09 | — | — | US | disclosed |
| US-20130338085-A1 | MUCIN HYPERSECRETION INHIBITORS AND METHODS OF USE | BIOMARCK PHARMACEUTICALS, LTD. | 2013-12-19 | — | — | US | disclosed |
| US-8492518-B2 | Mucin hypersecretion inhibitors and methods of use | BIOMARCK PHARMACEUTICALS LTD. (US) | 2013-07-23 | — | — | US | disclosed |
| US-8293870-B2 | Mucin hypersecretion inhibitors and methods of use | BIOMARCK PHARMACEUTICALS LTD (US) | 2012-10-23 | — | — | US | disclosed |
| EP-2399599-A2 | MUCIN HYPERSECRETION INHIBITORS AND METHODS OF USE | Biomarck Pharmaceuticals, Ltd. (US) | 2011-12-28 | — | — | EP | disclosed |
| US-20100197607-A1 | MUCIN HYPERSECRETION INHIBITORS AND METHODS OF USE | WILLIAMS, MASON L. | 2010-08-05 | — | — | US | disclosed |
| US-20090275520-A1 | MUCIN HYPERSECRETION INHIBITORS AND METHODS OF USE | WILLIAMS, MASON L. | 2009-11-05 | — | — | US | disclosed |
| US-7524926-B2 | Mucin hypersecretion inhibitors and methods of use | BIOMARCK PHARMACEUTICALS, LTD. (US) | 2009-04-28 | — | — | US | disclosed |
| US-20060205664-A1 | Mucin hypersecretion inhibitors and methods of use | WILLIAMS, MASON L. | 2006-09-14 | — | — | US | disclosed |