Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.32 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1759384 | 0.84 | CHRM3 (0.41) | CHRM3PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL17376370 | 0.82 | CHRM3 (0.40) | CHRM3PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL27952825 | 0.69 | CDK2 (0.55) | RAB9ACCNA2CDK2CCNA1KMT2A | |
| SCHEMBL8078173 | 0.67 | KMT2A (0.34) | RAB9ACCNA2CDK2CCNA1KMT2A | |
| SCHEMBL1759440 | 0.66 | PDE10A (0.50) | CHRM3PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL27869897 | 0.65 | CHRM3 (0.46) | CHRM3PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL21306244 | 0.65 | CHRM3 (0.36) | CHRM3PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11733107 | 0.64 | RAB9A (0.37) | HSP90AA1RAB9ACYP1A2ALDH1A1MAPT | |
| SCHEMBL2571631 | 0.64 | HSP90AA1 (0.36) | HSP90AA1RAB9AKMT2AMEN1TDP1 | |
| SCHEMBL4428463 | 0.63 | PDE10A (0.45) | CHRM3PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106488919-B | 3-substituted 2-aminoindole derivatives | 武田药品工业株式会社 | 2018-10-23 | — | — | CN | disclosed |
| US-10059713-B2 | 3-substituted 2-amino-indole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-08-28 | — | — | US | disclosed |
| US-20170158700-A1 | 3-SUBSTITUTED 2-AMINO-INDOLE DERIVATIVES | TAKEDA CAMBRIDGE LIMITED (GB) | 2017-06-08 | — | — | US | disclosed |
| US-20170158700-A1 | 3-SUBSTITUTED 2-AMINO-INDOLE DERIVATIVES | TAKEDA CAMBRIDGE LIMITED (GB) | 2017-06-08 | — | — | US | disclosed |
| US-20170158700-A1 | 3-SUBSTITUTED 2-AMINO-INDOLE DERIVATIVES | TAKEDA CAMBRIDGE LIMITED (GB) | 2017-06-08 | — | — | US | disclosed |
| EP-3160965-A1 | 3-SUBSTITUTED 2-AMINO-INDOLE DERIVATIVES | Takeda Pharmaceutical Company Limited (JP) | 2017-05-03 | — | — | EP | disclosed |
| CN-106488919-A | 3-substituted 2-aminoindole derivatives | 武田药品工业株式会社 | 2017-03-08 | — | — | CN | disclosed |
| WO-2015198045-A1 | 3-SUBSTITUTED 2-AMINO-INDOLE DERIVATIVES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-12-30 | — | — | WO | disclosed |
| WO-2015198045-A1 | 3-SUBSTITUTED 2-AMINO-INDOLE DERIVATIVES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10059713-B2 | 3-substituted 2-amino-indole derivatives | NPY5R, XDH, NPY4R | CHRM3 91/4885PDE4A 550/4885PDE4B 373/4885 |
| US-20170158700-A1 | 3-SUBSTITUTED 2-AMINO-INDOLE DERIVATIVES | NPY5R, XDH, NPY4R | CHRM3 91/4885PDE4A 550/4885PDE4B 373/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.