Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | FFAR2 | O15552 | 16/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17377302 | 0.83 | FFAR2 (0.47) | KDM4EALDH1A1GAAKMT2AHPGD | |
| SCHEMBL17377197 | 0.80 | KDM4E (0.51) | KDM4EALDH1A1GAAKMT2AHPGD | |
| SCHEMBL17377290 | 0.77 | KDM4E (0.47) | KDM4EALDH1A1GAAKMT2AHPGD | |
| SCHEMBL19743040 | 0.75 | FFAR2 (0.48) | KDM4EALDH1A1GAAFFAR2 | |
| SCHEMBL17376395 | 0.71 | FFAR2 (0.70) | FFAR2 | |
| SCHEMBL17379138 | 0.69 | KDM4E (0.48) | KDM4EALDH1A1GAAKMT2AHPGD | |
| SCHEMBL17377218 | 0.68 | ALDH1A1 (0.47) | KDM4EALDH1A1GAAKMT2AHPGD | |
| SCHEMBL17377301 | 0.66 | FFAR2 (0.50) | KDM4EALDH1A1GAAFFAR2 | |
| SCHEMBL17377182 | 0.66 | FFAR2 (0.48) | KDM4EALDH1A1GAAKMT2AHPGD | |
| SCHEMBL17377310 | 0.65 | GAA (0.51) | KDM4EALDH1A1GAAKMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3160955-A1 | 1,3-SUBSTITUTED 2-AMINOINDOLE DERIVATIVES AND ANALOGUES USEFUL IN THE TREATMENT OR PREVENTION OF DIABETES MELLITUS, OBESITY AND INFLAMMATORY BOWEL DISEASE | Takeda Pharmaceutical Company Limited (JP) | 2017-05-03 | — | — | EP | disclosed |
| WO-2015198046-A1 | 1,3-SUBSTITUTED 2-AMINOINDOLE DERIVATIVES AND ANALOGUES USEFUL IN THE TREATMENT OR PREVENTION OF DIABETES MELLITUS, OBESITY AND INFLAMMATORY BOWEL DISEASE | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-12-30 | — | — | WO | disclosed |