Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.36 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.36 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1738498 | 0.98 | NPSR1 (0.41) | NPSR1EPHX1DGAT1PDK1PDK2 | |
| SCHEMBL11477919 | 0.79 | ALDH1A1 (0.38) | CHRM3ALDH1A1 | |
| SCHEMBL16732111 | 0.79 | EPHX1 (0.38) | NPSR1EPHX1DGAT1SSTR4SMN1; SMN2 | |
| SCHEMBL11708952 | 0.79 | EPHX1 (0.38) | NPSR1EPHX1DGAT1PDK1PDK2 | |
| SCHEMBL29122830 | 0.77 | EPHX1 (0.41) | NPSR1EPHX1DGAT1PDK1PDK2 | |
| SCHEMBL16732092 | 0.77 | EPHX1 (0.41) | NPSR1EPHX1DGAT1PDK1PDK2 | |
| SCHEMBL11482835 | 0.77 | EPHX2 (0.39) | NPSR1EPHX1PDK1PDK2PDK3 | |
| SCHEMBL4956011 | 0.77 | EPHX1 (0.41) | NPSR1EPHX1DGAT1PDK1PDK2 | |
| SCHEMBL28730098 | 0.76 | KEAP1 (0.44) | EPHX1PDK1PDK2PDK3PDK4 | |
| SCHEMBL13840417 | 0.76 | EPHX2 (0.34) | NPSR1EPHX1DGAT1PDK1PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2389374-A1 | SUBSTITUTED PYRAZINONE AMIDES | Pfizer Inc. (US) | 2011-11-30 | — | — | EP | disclosed |
| US-20110254560-A1 | Electrical Systems and Battery Assemblies | KDT ACL INVESTMENTS, LLC | 2011-10-20 | — | — | US | disclosed |
| WO-2010084428-A1 | SUBSTITUTED PYRAZINONE AMIDES | PFIZER INC. (US) | 2010-07-29 | — | — | WO | disclosed |