Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 17/20 | 0.50 |
| ▸ | MKNK2 | Q9HBH9 | 16/20 | 0.50 |
| ▸ | EIF4E | P06730 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL173589 | 0.82 | MEN1 (0.58) | — | |
| SCHEMBL31158071 | 0.76 | MKNK2 (0.47) | MKNK1MKNK2EIF4E | |
| SCHEMBL255387 | 0.76 | MKNK2 (0.47) | MKNK1MKNK2EIF4E | |
| SCHEMBL4391902 | 0.71 | MAPK10 (0.56) | MKNK1MKNK2 | |
| SCHEMBL162573 | 0.70 | MKNK2 (0.52) | MKNK1MKNK2EIF4E | |
| SCHEMBL4762360 | 0.70 | MKNK1 (0.53) | MKNK1MKNK2EIF4E | |
| SCHEMBL16794668 | 0.70 | TYK2 (0.56) | — | |
| SCHEMBL174059 | 0.69 | MKNK1 (0.46) | MKNK1MKNK2EIF4E | |
| SCHEMBL1047675 | 0.69 | GSK3A (0.41) | MKNK1MKNK2EIF4E | |
| SCHEMBL4630887 | 0.69 | GSK3A (0.53) | MKNK1MKNK2EIF4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611790-A1 | PYRIDINONES/PYRAZINONES, METHOD OF MAKING, AND METHOD OF USE THEREOF | Gilead Connecticut, Inc. (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012031004-A1 | PYRIDINONES/PYRAZINONES, METHOD OF MAKING, AND METHOD OF USE THEREOF | GILEAD CONNECTICUT, INC. (US) | 2012-03-08 | — | — | WO | disclosed |