Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK2 | Q9HBH9 | 13/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 12/20 | 0.47 |
| ▸ | EIF4E | P06730 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 5/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL255387 | 1.00 | MKNK2 (0.47) | MKNK2MKNK1EIF4EBTKGSK3A | |
| SCHEMBL105801 | 0.82 | MEN1 (0.47) | BTK | |
| SCHEMBL29742044 | 0.82 | MEN1 (0.47) | BTK | |
| SCHEMBL10290275 | 0.80 | SORT1 (0.40) | MKNK2MKNK1 | |
| SCHEMBL14917627 | 0.80 | BTK (0.39) | MKNK2MKNK1EIF4EBTKCLK4 | |
| SCHEMBL14917675 | 0.80 | MKNK1 (0.42) | MKNK1BTK | |
| SCHEMBL12602969 | 0.78 | BTK (0.46) | BTK | |
| SCHEMBL1725758 | 0.77 | BTK (0.39) | BTK | |
| SCHEMBL14933856 | 0.77 | BTK (0.35) | BTK | |
| SCHEMBL10255868 | 0.77 | MAPK14 (0.47) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240270747-A1 | HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS | GENENTECH, INC. (US) | 2024-08-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240270747-A1 | HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS | PDXK, BTK, TYK2 | MKNK2 246/4885MKNK1 328/4885EIF4E 3899/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.