Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.58 |
| ▸ | GFER | P55789 | 1/20 | 0.58 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | TLR4 | O00206 | 1/20 | 0.38 |
| ▸ | TLR2 | O60603 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL173840 | 0.82 | MKNK1 (0.50) | — | |
| SCHEMBL105801 | 0.77 | MEN1 (0.47) | MEN1KMT2AMAPK10GFERTYK2 | |
| SCHEMBL29742044 | 0.77 | MEN1 (0.47) | MEN1KMT2AMAPK10GFERTYK2 | |
| SCHEMBL3279571 | 0.75 | MEN1 (1.00) | MEN1KMT2AMAPK10GFERALDH1A1 | |
| SCHEMBL24374650 | 0.74 | MEN1 (0.44) | MEN1KMT2AMAPK10GFERTYK2 | |
| SCHEMBL16794668 | 0.72 | TYK2 (0.56) | TYK2 | |
| SCHEMBL31398195 | 0.71 | AURKA (0.41) | TYK2ALDH1A1LRRK2 | |
| SCHEMBL31743130 | 0.71 | APAF1 (0.43) | BTK | |
| SCHEMBL7941542 | 0.71 | MAPK10 (0.73) | MEN1KMT2AMAPK10GFERALDH1A1 | |
| SCHEMBL31220877 | 0.71 | MAPK10 (0.73) | MEN1KMT2AMAPK10GFERALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611790-A1 | PYRIDINONES/PYRAZINONES, METHOD OF MAKING, AND METHOD OF USE THEREOF | Gilead Connecticut, Inc. (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012031004-A1 | PYRIDINONES/PYRAZINONES, METHOD OF MAKING, AND METHOD OF USE THEREOF | GILEAD CONNECTICUT, INC. (US) | 2012-03-08 | — | — | WO | disclosed |