Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | FABP4 | P15090 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GPR183 | P32249 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17418007 | 0.89 | TSHR (0.45) | LMNAKDM4EGPR183RAB9ANPC1 | |
| SCHEMBL17429674 | 0.79 | PTGER3 (0.47) | LMNAKDM4ERAB9ANPC1SMN1; SMN2 | |
| SCHEMBL17385947 | 0.78 | FFAR1 (0.41) | LMNAALDH1A1MAPK1 | |
| SCHEMBL17385984 | 0.78 | TSHR (0.43) | LMNAFABP4KDM4ERAB9ANPC1 | |
| SCHEMBL17386253 | 0.77 | ALDH1A1 (0.44) | LMNAKDM4ERAB9ANPC1SMN1; SMN2 | |
| SCHEMBL17386246 | 0.77 | TSHR (0.39) | LMNAKDM4ERAB9ANPC1SMN1; SMN2 | |
| SCHEMBL17385995 | 0.76 | LMNA (0.39) | LMNARAB9ANPC1MAPTALDH1A1 | |
| SCHEMBL17386007 | 0.76 | FFAR1 (0.39) | LMNARAB9ANPC1SMN1; SMN2PTGER3 | |
| SCHEMBL17400069 | 0.76 | TSHR (0.38) | LMNAKDM4ERAB9ANPC1SMN1; SMN2 | |
| SCHEMBL6293635 | 0.74 | ALDH1A1 (0.51) | FABP4RAB9ANPC1PKMTTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2963027-B1 | TRICYCLIC COMPOUND AND USE THEREOF | TIUMBIO CO LTD (KR) | 2018-12-26 | — | — | EP | disclosed |
| EP-2963027-A1 | TRICYCLIC COMPOUND AND USE THEREOF | SK Chemicals Co., Ltd. (KR) | 2016-01-06 | — | — | EP | disclosed |