Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 5/20 | 0.35 |
| ▸ | MAPK7 | Q13164 | 2/20 | 0.35 |
| ▸ | WEE1 | P30291 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | FPR2 | P25090 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | PER2 | O15055 | 1/20 | 0.34 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1737221 | 1.00 | DPP4 (0.37) | DPP4PARP1PARP2ALDH1A1L3MBTL1 | |
| SCHEMBL1737782 | 1.00 | DPP4 (0.37) | DPP4PARP1PARP2ALDH1A1L3MBTL1 | |
| SCHEMBL1738502 | 0.95 | DPP4 (0.38) | DPP4PARP1PARP2ALDH1A1L3MBTL1 | |
| SCHEMBL1737851 | 0.95 | DPP4 (0.38) | DPP4PARP1PARP2ALDH1A1L3MBTL1 | |
| SCHEMBL1738798 | 0.95 | DPP4 (0.38) | DPP4PARP1PARP2ALDH1A1L3MBTL1 | |
| SCHEMBL1737739 | 0.90 | CHRM4 (0.36) | DPP4PARP1PARP2SYKMAOA | |
| SCHEMBL1738446 | 0.89 | WEE1 (0.37) | PARP1PARP2WEE1FPR2 | |
| SCHEMBL1738510 | 0.89 | WEE1 (0.37) | PARP1PARP2WEE1FPR2 | |
| SCHEMBL1738975 | 0.89 | WEE1 (0.37) | PARP1PARP2WEE1FPR2 | |
| SCHEMBL1737882 | 0.87 | HTR6 (0.36) | DPP4ALDH1A1L3MBTL1MAPK7LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1727794-B1 | NOVEL BENZYL(IDENE)-LACTAM DERIVATIVES | PFIZER PROD INC (US) | 2011-11-16 | — | — | EP | claimed |
| US-20110263484-A1 | SINGLE CHAIN FC TYPE III INTERFERONS AND METHODS OF USING SAME | ZYMOGENETICS, INC. | 2011-10-27 | — | — | US | claimed |
| US-7479559-B2 | 3-[-2-(Piperazin-1-yl)benzyl]pyrrolidin-2-one derivatives; antidepressants, anxiolytic agents; obsessive compulsive disorder, psychological disorders, phobias; 5-HT1 agonist or antagonists; side effect reduction, in particular cardiac QTc prolongation; hydrogenation | PFIZER INC. (US) | 2009-01-20 | — | — | US | claimed |