Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WEE1 | P30291 | 9/20 | 0.37 |
| ▸ | PLK1 | P53350 | 8/20 | 0.37 |
| ▸ | BRD9 | Q9H8M2 | 4/20 | 0.36 |
| ▸ | BRPF1 | P55201 | 3/20 | 0.36 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | NCF1 | P14598 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.35 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.35 |
| ▸ | FPR2 | P25090 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1738510 | 1.00 | WEE1 (0.37) | WEE1PLK1BRD9BRPF1BRD4 | |
| SCHEMBL1738975 | 1.00 | WEE1 (0.37) | WEE1PLK1BRD9BRPF1BRD4 | |
| SCHEMBL1737753 | 0.95 | ROCK2 (0.40) | WEE1PLK1BRD9BRPF1BRD4 | |
| SCHEMBL1738670 | 0.95 | ROCK2 (0.40) | WEE1PLK1BRD9BRPF1BRD4 | |
| SCHEMBL1737725 | 0.95 | ROCK2 (0.40) | WEE1PLK1BRD9BRPF1BRD4 | |
| SCHEMBL1737277 | 0.90 | CHRM4 (0.39) | PARP1PARP2ROCK2FPR2CHRM4 | |
| SCHEMBL1738829 | 0.89 | DPP4 (0.37) | WEE1PARP1PARP2FPR2 | |
| SCHEMBL1737782 | 0.89 | DPP4 (0.37) | WEE1PARP1PARP2FPR2 | |
| SCHEMBL1737221 | 0.89 | DPP4 (0.37) | WEE1PARP1PARP2FPR2 | |
| SCHEMBL1738321 | 0.86 | FPR2 (0.43) | BRD9BRPF1BRD4NCF1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1727794-B1 | NOVEL BENZYL(IDENE)-LACTAM DERIVATIVES | PFIZER PROD INC (US) | 2011-11-16 | — | — | EP | claimed |
| US-20110263484-A1 | SINGLE CHAIN FC TYPE III INTERFERONS AND METHODS OF USING SAME | ZYMOGENETICS, INC. | 2011-10-27 | — | — | US | claimed |
| US-7479559-B2 | 3-[-2-(Piperazin-1-yl)benzyl]pyrrolidin-2-one derivatives; antidepressants, anxiolytic agents; obsessive compulsive disorder, psychological disorders, phobias; 5-HT1 agonist or antagonists; side effect reduction, in particular cardiac QTc prolongation; hydrogenation | PFIZER INC. (US) | 2009-01-20 | — | — | US | claimed |
| WO-2007026224-A2 | 5-HT1B ANTAGONIST COMPOSITION FOR DEPRESSION, ANXIETY AND COGNITION | PFIZER PRODUCTS INC. (US) | 2007-03-08 | — | — | WO | claimed |
| WO-2007026219-A2 | COMBINATIONS OF A 5-HT1B ANTAGONIST WITH A NORADRENALIN RE-UPTAKE INHIBITOR OR A SEROTONIN NORADRENALIN REUTAKE INHIBITOR FOR TREATING CNS CONDITIONS | PFIZER PRODUCTS INC. (US) | 2007-03-08 | — | — | WO | disclosed |
| WO-2007026224-A2 | 5-HT1B ANTAGONIST COMPOSITION FOR DEPRESSION, ANXIETY AND COGNITION | PFIZER PRODUCTS INC. (US) | 2007-03-08 | — | — | WO | disclosed |