SCHEMBL173886

SCHEMBL173886

CN(C(=O)O)c1c(N)nc(-c2nn(Cc3ccccc3F)c3ncc(F)cc23)nc1N

nearest known ligand 0.64

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 1/20 0.64
KCNH2 Q12809 1/20 0.64
GUCY1A1 Q02108 2/20 0.57
GUCY1B1 Q02153 2/20 0.57
PDE5A O76074 16/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL427311 0.99 ADORA3 (0.63) ADORA3KCNH2GUCY1A1GUCY1B1PDE5A
Sulfuric Acid SCHEMBL428371 0.97 ADORA3 (0.61) ADORA3KCNH2GUCY1A1GUCY1B1PDE5A
Phosphoric Acid SCHEMBL430663 0.97 ADORA3 (0.61) ADORA3KCNH2GUCY1A1GUCY1B1PDE5A
SCHEMBL431126 0.96 ADORA3 (0.62) ADORA3KCNH2GUCY1A1GUCY1B1PDE5A
Maleic Acid SCHEMBL427303 0.96 ADORA3 (0.60) ADORA3KCNH2GUCY1A1GUCY1B1PDE5A
Fumaric Acid SCHEMBL427304 0.96 ADORA3 (0.60) ADORA3KCNH2GUCY1A1GUCY1B1PDE5A
Nitric Acid SCHEMBL429168 0.95 ADORA3 (0.59) ADORA3KCNH2GUCY1A1GUCY1B1PDE5A
Nitric Acid SCHEMBL429167 0.95 ADORA3 (0.59) ADORA3KCNH2GUCY1A1GUCY1B1PDE5A
SCHEMBL430662 0.94 ADORA3 (0.58) ADORA3KCNH2GUCY1A1GUCY1B1PDE5A
SCHEMBL10083045 0.91 KCNH2 (0.79) ADORA3KCNH2GUCY1A1GUCY1B1PDE5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 71 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3790546-B1 NON-STEROIDAL MINERALOCORTICOID RECEPTOR ANTAGONISTS ALONE OR IN COMBINATION FOR USE IN THE TREATMENT OF MUSCULAR OR NEUROMUSCULAR DISEASES BAYER AG (DE) 2024-08-21 EP claimed
EP-3525779-B1 COMBINATION CONTAINING THE SGC STIMULATOR VERICUGUAT AND THE MINERALCORTICOID RECEPTOR ANTAGONIST FINERENONE Bayer Pharma AG (DE) 2024-06-05 EP claimed
US-20210052528-A1 THE USE OF SGC ACTIVATORS AND SGC STIMULATORS FOR THE TREATMENT OF COGNITIVE IMPAIRMENT BAYER AKTIENGESELLSCHAFT (DE) 2021-02-25 US claimed
US-20200397785-A1 SUBSTITUTED 5-FLUORO-1H-PYRAZOLOPYRIDINES AND THEIR USE ADVERIO PHARMA GMBH (DE) 2020-12-24 US claimed
EP-3291811-B1 THE USE OF SGC STIMULATORS, SGC ACTIVATORS, ALONE AND COMBINATIONS WITH PDE5 INHIBITORS FOR THE TREATMENT OF DIGITAL ULCERS (DU) CONCOMITANT TO SYSTEMIC SCLEROSIS (SSC) Bayer Pharma AG (DE) 2019-08-07 EP claimed
US-10265314-B2 SGC stimulators in combination with additional treatment for the therapy of cystic fibrosis BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2019-04-23 US claimed
US-20180263981-A1 SUBSTITUTED 5-FLUORO-1H-PYRAZOLOPYRIDINES AND THEIR USE ADVERIO PHARMA GMBH (DE) 2018-09-20 US claimed
US-20180169095-A1 THE USE OF SGC STIMULATORS, SGC ACTIVATORS, ALONE AND COMBINATIONS WITH PDE5 INHIBITORS FOR THE TREATMENT OF DIGITAL ULCERS (DU) CONCOMITANT TO SYSTEMIC SCLEROSIS (SSC) BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2018-06-21 US claimed
US-9993476-B2 Substituted 5-flouro-1H-pyrazolopyridines and their use ADVERIO PHARMA GMBH (DE) 2018-06-12 US claimed
EP-3291811-A1 THE USE OF SGC STIMULATORS, SGC ACTIVATORS, ALONE AND COMBINATIONS WITH PDE5 INHIBITORS FOR THE TREATMENT OF DIGITAL ULCERS (DU) CONCOMITANT TO SYSTEMIC SCLEROSIS (SSC) Bayer Pharma Aktiengesellschaft (DE) 2018-03-14 EP claimed
US-20160158233-A1 SGC STIMULATORS OR SGC ACTIVATORS AND PDE5 INHIBITORS IN COMBINATION WITH ADDITIONAL TREATMENT FOR THE THERAPY OF CYSTIC FIBROSIS BAYER PHARMA AKTIENGESELl SCHAFT (DE) 2016-06-09 US claimed
EP-3024455-A1 SGC STIMULATORS OR SGC ACTIVATORS AND PDE5 INHIBITORS IN COMBINATION WITH ADDITIONAL TREATMENT FOR THE THERAPY OF CYSTIC FIBROSIS Bayer Pharma Aktiengesellschaft (DE) 2016-06-01 EP claimed
US-9266885-B2 Substituted 5-fluoro-1H-pyrazolopyridines and their use ADVERIO PHARMA GMBH (DE) 2016-02-23 US claimed
EP-2576547-B1 SUBSTITUTED 5-FLUORO-1H-PYRAZOLOPYRIDINES AND USE THEREOF ADVERIO PHARMA GMBH (DE) 2016-01-27 EP claimed
US-20150080414-A1 SUBSTITUTED 5-FLUORO-1H-PYRAZOLOPYRIDINES AND THEIR USE BAYER INTELLECTUAL PROPERTY GMBH (DE) 2015-03-19 US claimed
WO-2015011086-A1 SGC STIMULATORS OR SGC ACTIVATORS AND PDE5 INHIBITORS IN COMBINATION WITH ADDITIONAL TREATMENT FOR THE THERAPY OF CYSTIC FIBROSIS BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2015-01-29 WO claimed
US-8921377-B2 Substituted 5-fluoro-1H-pyrazolopyridines and their use BAYER INTELLECTUAL PROPERTY GMBH (DE) 2014-12-30 US claimed
US-20130237551-A1 Substituted 5-fluoro-1H-pyrazolopyridines and their use BAYER INTELLECTUAL PROPERTY GMBH (DE) 2013-09-12 US claimed
US-8420656-B2 Substituted 5-fluoro-1H-pyrazolopyridines and their use BAYER INTELLECTUAL PROPERTY GMBH (DE) 2013-04-16 US claimed
US-20120022084-A1 Substituted 5-fluoro-1H-pyrazolopyridines and their use BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2012-01-26 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180169095-A1 THE USE OF SGC STIMULATORS, SGC ACTIVATORS, ALONE AND COMBINATIONS WITH PDE5 INHIBITORS FOR THE TREATMENT OF DIGITAL ULCERS (DU) CONCOMITANT TO SYSTEMIC SCLEROSIS (SSC) PDE5A, PDE2A, PDE3A ADORA3 3072/4885KCNH2 2945/4885GUCY1A1 11/4885
US-20180263981-A1 SUBSTITUTED 5-FLUORO-1H-PYRAZOLOPYRIDINES AND THEIR USE PFKP, PON1, FABP3 ADORA3 1633/4885KCNH2 128/4885GUCY1A1 1337/4885
US-20150080414-A1 SUBSTITUTED 5-FLUORO-1H-PYRAZOLOPYRIDINES AND THEIR USE PFKP, PON1, FABP3 ADORA3 1633/4885KCNH2 128/4885GUCY1A1 1337/4885
US-20200397785-A1 SUBSTITUTED 5-FLUORO-1H-PYRAZOLOPYRIDINES AND THEIR USE PFKP, PON1, FABP3 ADORA3 1633/4885KCNH2 128/4885GUCY1A1 1337/4885
US-20160158233-A1 SGC STIMULATORS OR SGC ACTIVATORS AND PDE5 INHIBITORS IN COMBINATION WITH ADDITIONAL TREATMENT FOR THE THERAPY OF CYSTIC FIBROSIS PDE5A, PDE3A, GMPS ADORA3 1527/4885KCNH2 1661/4885GUCY1A1 7/4885
US-20210052528-A1 THE USE OF SGC ACTIVATORS AND SGC STIMULATORS FOR THE TREATMENT OF COGNITIVE IMPAIRMENT GUCY1A2, GUCY1A1, PRKG1 ADORA3 1349/4885KCNH2 2540/4885GUCY1A1 2/4885
US-20130237551-A1 Substituted 5-fluoro-1H-pyrazolopyridines and their use PFKP, PON1, FABP3 ADORA3 1633/4885KCNH2 128/4885GUCY1A1 1337/4885
US-10265314-B2 SGC stimulators in combination with additional treatment for the therapy of cystic fibrosis PDE5A, GMPS, PDE3A ADORA3 1351/4885KCNH2 1467/4885GUCY1A1 9/4885
US-20120022084-A1 Substituted 5-fluoro-1H-pyrazolopyridines and their use PFKP, PON1, FABP3 ADORA3 1633/4885KCNH2 128/4885GUCY1A1 1337/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.