SCHEMBL1739012

SCHEMBL1739012

COc1cccc(Cn2c(C)c(C)c3cc(CN4CCN(C)CC4)nc(N4CCc5ccccc5C4)c32)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 1/20 0.41
HTR1A P08908 2/20 0.40
HTR1D P28221 1/20 0.40
HTR1B P28222 1/20 0.40
ALDH1A1 P00352 5/20 0.40
USP2 O75604 3/20 0.40
CYP3A4 P08684 3/20 0.40
CYP2C19 P33261 1/20 0.40
MEN1 O00255 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C9 P11712 1/20 0.40
KMT2A Q03164 1/20 0.40
HSD17B10 Q99714 1/20 0.40
CLK4 Q9HAZ1 1/20 0.40
KDM4E B2RXH2 2/20 0.39
GAA P10253 1/20 0.39
DRD2 P14416 2/20 0.39
HTR2B P41595 1/20 0.39
EHMT2 Q96KQ7 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL1737097 0.99 SIGMAR1 (0.41) SIGMAR1HTR1AHTR1DHTR1BALDH1A1
SCHEMBL1738714 0.90 PRMT5 (0.40) ALDH1A1CYP2C19MEN1CYP1A2CYP2D6
SCHEMBL1737620 0.90 MC4R (0.40) ALDH1A1USP2CYP3A4CYP2C19CYP1A2
Hydrochloric Acid SCHEMBL1738465 0.89 PRMT5 (0.39) ALDH1A1CYP2C19MEN1CYP1A2CYP2D6
Hydrochloric Acid SCHEMBL1737914 0.89 MC4R (0.39) ALDH1A1USP2CYP3A4CYP2C19CYP1A2
SCHEMBL1736974 0.89 EHMT2 (0.36) ALDH1A1USP2MEN1KMT2AHSD17B10
SCHEMBL1737831 0.89 ALDH1A1 (0.45) SIGMAR1ALDH1A1USP2MEN1KMT2A
Hydrochloric Acid SCHEMBL1737175 0.88 EHMT2 (0.36) ALDH1A1USP2MEN1KMT2AHSD17B10
Hydrochloric Acid SCHEMBL1735928 0.88 ALDH1A1 (0.44) SIGMAR1ALDH1A1USP2MEN1KMT2A
SCHEMBL1736732 0.86 SIGMAR1 (0.40) SIGMAR1HTR1AALDH1A1USP2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1784404-B1 PYRROLO[2,3-C]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF YUHAN CORP (KR) 2011-11-16 EP claimed
US-20110263306-A1 COMPUTER SYSTEM AND PROGRAM NAMCO BANDAI GAMES INC. (JP) 2011-10-27 US claimed