SCHEMBL17390707

SCHEMBL17390707

CCOC(=O)c1nnc(CCCCO)s1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 1/20 0.47
CYP2C9 P11712 1/20 0.46
ALDH1A1 P00352 3/20 0.45
AKT1 P31749 1/20 0.42
IRS1 P35568 1/20 0.42
GAB1 Q13480 1/20 0.42
RECQL P46063 1/20 0.41
GLS O94925 4/20 0.40
POLB P06746 1/20 0.40
HSD17B10 Q99714 3/20 0.39
GAA P10253 2/20 0.39
KMT2A Q03164 1/20 0.39
CYP4F2 P78329 2/20 0.38
CYP4A11 Q02928 2/20 0.38
HPGD P15428 2/20 0.37
MAPT P10636 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
KDM4E B2RXH2 1/20 0.36
USP2 O75604 1/20 0.36
TSHR P16473 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31497061 0.94 NPSR1 (0.51) NPSR1CYP2C9ALDH1A1AKT1IRS1
SCHEMBL17402505 0.89 NPSR1 (0.58) NPSR1CYP2C9ALDH1A1AKT1IRS1
SCHEMBL31497070 0.84 NPSR1 (0.47) NPSR1CYP2C9ALDH1A1AKT1IRS1
SCHEMBL19558977 0.84 RECQL (0.56) NPSR1CYP2C9ALDH1A1AKT1IRS1
SCHEMBL17405128 0.83 NPSR1 (0.49) NPSR1CYP2C9ALDH1A1AKT1IRS1
SCHEMBL13477788 0.82 GAA (0.44) ALDH1A1AKT1IRS1GAB1RECQL
SCHEMBL17079289 0.81 POLB (0.46) NPSR1CYP2C9ALDH1A1AKT1IRS1
SCHEMBL17288767 0.81 ALDH1A1 (0.42) NPSR1CYP2C9ALDH1A1AKT1IRS1
SCHEMBL17396758 0.81 NPSR1 (0.41) NPSR1CYP2C9ALDH1A1AKT1IRS1
SCHEMBL17390393 0.81 AKT1 (0.43) NPSR1CYP2C9ALDH1A1AKT1IRS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240360121-A1 GLS1 INHIBITORS FOR TREATING DISEASE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2024-10-31 US disclosed
US-11958849-B2 GLS1 inhibitors for treating disease BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2024-04-16 US disclosed
US-20230124815-A1 GLS1 INHIBITORS FOR TREATING DISEASE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2023-04-20 US disclosed
US-20230124815-A1 GLS1 INHIBITORS FOR TREATING DISEASE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2023-04-20 US disclosed
US-11370786-B2 GLS1 inhibitors for treating disease BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2022-06-28 US disclosed
US-11370786-B2 GLS1 inhibitors for treating disease BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2022-06-28 US disclosed
CN-107074805-B GLS1 inhibitors for the treatment of disease 德州大学系统董事会 2021-02-26 CN disclosed
US-20200407353-A1 GLS1 INHIBITORS FOR TREATING DISEASE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2020-12-31 US disclosed
US-20200407353-A1 GLS1 INHIBITORS FOR TREATING DISEASE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2020-12-31 US disclosed
US-10766892-B2 GLS1 inhibitors for treating disease BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2020-09-08 US disclosed
US-20160009704-A1 GLS1 INHIBITORS FOR TREATING DISEASE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2016-01-14 US disclosed
US-20160009704-A1 GLS1 INHIBITORS FOR TREATING DISEASE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2016-01-14 US disclosed
US-20160009704-A1 GLS1 INHIBITORS FOR TREATING DISEASE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2016-01-14 US disclosed
WO-2016004404-A2 GLS1 INHIBITORS FOR TREATING DISEASE BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM (US) 2016-01-07 WO disclosed
WO-2016004417-A1 GLS1 INHIBITORS FOR TREATING DISEASE BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM (US) 2016-01-07 WO disclosed
WO-2016004404-A2 GLS1 INHIBITORS FOR TREATING DISEASE BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM (US) 2016-01-07 WO disclosed
WO-2016004417-A1 GLS1 INHIBITORS FOR TREATING DISEASE BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM (US) 2016-01-07 WO disclosed
US-20160002204-A1 GLS1 INHIBITORS FOR TREATING DISEASE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2016-01-07 US disclosed
US-20160002204-A1 GLS1 INHIBITORS FOR TREATING DISEASE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2016-01-07 US disclosed
US-20160002204-A1 GLS1 INHIBITORS FOR TREATING DISEASE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2016-01-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240360121-A1 GLS1 INHIBITORS FOR TREATING DISEASE GLS2, GLS, GLG1 NPSR1 2383/4885CYP2C9 3264/4885ALDH1A1 882/4885
US-20230124815-A1 GLS1 INHIBITORS FOR TREATING DISEASE GLS2, GLS, GLG1 NPSR1 2383/4885CYP2C9 3264/4885ALDH1A1 882/4885
US-20160009704-A1 GLS1 INHIBITORS FOR TREATING DISEASE GLS2, GLS, GLG1 NPSR1 2383/4885CYP2C9 3264/4885ALDH1A1 882/4885
US-10766892-B2 GLS1 inhibitors for treating disease GLS2, GLS, GLG1 NPSR1 2383/4885CYP2C9 3264/4885ALDH1A1 882/4885
US-11370786-B2 GLS1 inhibitors for treating disease GLS2, GLS, GLB1 NPSR1 2582/4885CYP2C9 2860/4885ALDH1A1 766/4885
US-11958849-B2 GLS1 inhibitors for treating disease GLS2, GLS, GLG1 NPSR1 2383/4885CYP2C9 3264/4885ALDH1A1 882/4885
US-20160002204-A1 GLS1 INHIBITORS FOR TREATING DISEASE GLS2, GLS, GLG1 NPSR1 2383/4885CYP2C9 3264/4885ALDH1A1 882/4885
US-20200407353-A1 GLS1 INHIBITORS FOR TREATING DISEASE GLS2, GLS, GLG1 NPSR1 2383/4885CYP2C9 3264/4885ALDH1A1 882/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.