Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 2/20 | 1.00 |
| ▸ | PARP1 | P09874 | 5/20 | 0.75 |
| ▸ | PARP10 | Q53GL7 | 5/20 | 0.75 |
| ▸ | PARP14 | Q460N5 | 4/20 | 0.75 |
| ▸ | PARP15 | Q460N3 | 3/20 | 0.75 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.75 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.70 |
| ▸ | MAPT | P10636 | 4/20 | 0.70 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.70 |
| ▸ | MEN1 | O00255 | 5/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17395887 | 1.00 | CREBBP (1.00) | CREBBPPARP1PARP10PARP14PARP15 | |
| SCHEMBL11011741 | 0.89 | CREBBP (0.81) | CREBBPPARP1PARP10PARP14PARP15 | |
| SCHEMBL11011737 | 0.89 | CREBBP (0.81) | CREBBPPARP1PARP10PARP14PARP15 | |
| SCHEMBL15798246 | 0.89 | CREBBP (0.79) | CREBBPPARP1PARP10PARP14PARP15 | |
| SCHEMBL9364423 | 0.89 | CREBBP (0.79) | CREBBPPARP1PARP10PARP14PARP15 | |
| SCHEMBL9364431 | 0.89 | CREBBP (0.79) | CREBBPPARP1PARP10PARP14PARP15 | |
| SCHEMBL441804 | 0.86 | LPAR2 (1.00) | CREBBPPARP1PARP10PARP14PARP15 | |
| SCHEMBL1552033 | 0.86 | LPAR2 (1.00) | CREBBPPARP1PARP10PARP14PARP15 | |
| SCHEMBL441805 | 0.86 | LPAR2 (1.00) | CREBBPPARP1PARP10PARP14PARP15 | |
| Iodide SCHEMBL1552156 | 0.84 | LPAR2 (0.96) | CREBBPPARP1PARP10PARP14PARP15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| WO-2016001452-A1 | COMPOUNDS, IN PARTICULAR FOR USE IN THE TREATMENT OF A DISEASE OR CONDITION FOR WHICH A BROMODOMAIN INHIBITOR IS INDICATED | Universität Zürich (CH) | 2016-01-07 | — | — | WO | disclosed |
| WO-2016001452-A1 | COMPOUNDS, IN PARTICULAR FOR USE IN THE TREATMENT OF A DISEASE OR CONDITION FOR WHICH A BROMODOMAIN INHIBITOR IS INDICATED | Universität Zürich (CH) | 2016-01-07 | — | — | WO | disclosed |