SCHEMBL441804

SCHEMBL441804

O=C(O)/C=C\C(=O)Nc1cccc(NC(=O)/C=C\C(=O)O)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LPAR2 Q9HBW0 4/20 1.00
LPAR1 Q92633 2/20 1.00
ALDH1A1 P00352 6/20 0.78
MAPT P10636 5/20 0.78
LPAR3 Q9UBY5 4/20 0.78
CREBBP Q92793 1/20 0.75
PARP1 P09874 2/20 0.73
PARP15 Q460N3 2/20 0.73
PARP14 Q460N5 2/20 0.73
PARP10 Q53GL7 2/20 0.73
KDM4E B2RXH2 4/20 0.62
THRB P10828 2/20 0.61
TDP2 O95551 1/20 0.61
GAA P10253 1/20 0.61
L3MBTL1 Q9Y468 1/20 0.61
PKM P14618 1/20 0.61
NMT1 P30419 1/20 0.59
KMT2A Q03164 2/20 0.59
MEN1 O00255 1/20 0.59
SMN1; SMN2 Q16637 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1552033 1.00 LPAR2 (1.00) LPAR2LPAR1ALDH1A1MAPTLPAR3
SCHEMBL441805 1.00 LPAR2 (1.00) LPAR2LPAR1ALDH1A1MAPTLPAR3
Iodide SCHEMBL1552156 0.98 LPAR2 (0.96) LPAR2LPAR1ALDH1A1MAPTLPAR3
SCHEMBL19501839 0.91 LPAR2 (0.83) LPAR2LPAR1ALDH1A1MAPTLPAR3
SCHEMBL7457467 0.89 LPAR2 (0.80) LPAR2LPAR1ALDH1A1MAPTLPAR3
SCHEMBL6545766 0.89 LPAR2 (0.80) LPAR2LPAR1ALDH1A1MAPTLPAR3
SCHEMBL6545765 0.89 LPAR2 (0.80) LPAR2LPAR1ALDH1A1MAPTLPAR3
SCHEMBL19174293 0.88 ALDH1A1 (1.00) LPAR2LPAR1ALDH1A1MAPTLPAR3
SCHEMBL15798246 0.88 CREBBP (0.79) LPAR2LPAR1ALDH1A1MAPTLPAR3
SCHEMBL9838285 0.88 LPAR2 (0.77) LPAR2LPAR1ALDH1A1MAPTLPAR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8613298-B2 Functionalized elastomers THE GOODYEAR TIRE & RUBBER COMPANY (US) 2013-12-24 US claimed
EP-2119573-B1 Functionalized elastomers GOODYEAR TIRE & RUBBER (US) 2011-04-27 EP claimed
US-7534828-B2 e.g.natural rubber, neoprene, polyisoprene, butyl rubber, polybutadiene, styrene-butadiene copolymer as unsaturated elastomers; filler selected from carbon black and silica; N,N'-(m-phenylene)bismaleamic acid, zinc dibenzyl dithiocarbamate, a cure accelerators THE GOODYEAR TIRE & RUBBER COMPANY (US) 2009-05-19 US claimed
EP-1397402-B1 PROCESS FOR CROSS-LINKING A POLYMER SARTOMER TECHNOLOGY CO INC (US) 2006-08-09 EP claimed
US-6989425-B2 Process for cross-linking a polymer DSM IP ASSETS B.V. (NL) 2006-01-24 US claimed
US-20040147685-A1 Process for cross-linking a polymer SARTOMER TECHNOLOGY COMPANY, INC. 2004-07-29 US claimed
EP-1397402-A1 PROCESS FOR CROSS-LINKING A POLYMER DSM IP Assets B.V. (NL) 2004-03-17 EP claimed
WO-2002090408-A1 PROCESS FOR CROSS-LINKING A POLYMER DSM IP ASSETS B.V. (NL) 2002-11-14 WO claimed
JP-61083158-A None JP disclosed
JP-61293964-A None JP disclosed
US-9550839-B2 Copolymers of conjugated triene monomers for improved filler interaction THE GOODYEAR TIRE & RUBBER COMPANY (US) 2017-01-24 US disclosed
US-20150376343-A1 COPOLYMERS OF CONJUGATED TRIENE MONOMERS FOR IMPROVED FILLER INTERACTION THE GOODYEAR TIRE & RUBBER COMPANY (US) 2015-12-31 US disclosed
US-9079980-B2 Copolymers of conjugated triene monomers for improved filler interaction THE GOODYEAR TIRE & RUBBER COMPANY (US) 2015-07-14 US disclosed
US-8613298-B2 Functionalized elastomers THE GOODYEAR TIRE & RUBBER COMPANY (US) 2013-12-24 US disclosed
EP-0036097-A2 Glass fibres for the reinforcement of polyolefins and reinforced polyolefin compositions obtained therefrom Montedison S.p.A. (IT) 1981-09-23 EP disclosed
US-4278586-A BIS-MALEAMIC ACID MONTEDISON S.P.A. (IT) 1981-07-14 US disclosed
US-4179444-A Process for the manufacture of iso-imides or mixtures of iso-imides and imides CIBA-GEIGY CORPORATION (US) 1979-12-18 US disclosed
US-4154737-A FROM MALEIC ANHYDRIDE AND PRIMARY AMINES, MAGNESIUM SALT CATALYST WITH TERTIARY AMINE E. I. DU PONT DE NEMOURS AND COMPANY (US) 1979-05-15 US disclosed
US-4130564-A CYCLODEHYDRATION CIBA-GEIGY CORPORATION (US) 1978-12-19 US disclosed
US-3984373-A EPOXY RESINS, N,N*-UNSATURATED AMIC ACIDS HITACHI, LTD. (JA) 1976-10-05 US disclosed