Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 3/20 | 0.44 |
| ▸ | TRPM5 | Q9NZQ8 | 8/20 | 0.39 |
| ▸ | TRPM4 | Q8TD43 | 6/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.36 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.36 |
| ▸ | ITGAV | P06756 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.36 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.36 |
| ▸ | ITGAL | P20701 | 1/20 | 0.36 |
| ▸ | PYGL | P06737 | 1/20 | 0.34 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.33 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17396985 | 0.83 | AKR1B1 (0.44) | AKR1B1ITGB3ITGB2ITGB1ITGAV | |
| SCHEMBL17396988 | 0.83 | AKR1B1 (0.41) | AKR1B1ITGB3ITGB2ITGB1ITGAV | |
| SCHEMBL17396998 | 0.83 | AKR1B1 (0.41) | AKR1B1ITGB3ITGB2ITGB1ITGAV | |
| SCHEMBL20537362 | 0.83 | AKR1B1 (0.44) | AKR1B1ITGB3ITGB2ITGB1ITGAV | |
| SCHEMBL27528311 | 0.77 | ITGB3 (0.47) | AKR1B1TRPM5TRPM4ITGB3ITGB2 | |
| SCHEMBL11172644 | 0.70 | POLB (0.47) | AKR1B1 | |
| SCHEMBL17363890 | 0.69 | NR3C1 (0.42) | AKR1B1NR3C1NR3C2 | |
| SCHEMBL17363948 | 0.69 | NR3C1 (0.42) | AKR1B1NR3C1NR3C2 | |
| SCHEMBL17363934 | 0.69 | NR3C1 (0.42) | AKR1B1NR3C1NR3C2 | |
| SCHEMBL7293280 | 0.68 | TBXA2R (0.42) | ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3160948-A1 | BENZOXAZINONE AMIDES AS MINERALOCORTICOID RECEPTOR MODULATORS | Astrazeneca AB (SE) | 2017-05-03 | — | — | EP | disclosed |
| WO-2016001631-A1 | BENZOXAZINONE AMIDES AS MINERALOCORTICOID RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2016-01-07 | — | — | WO | disclosed |