Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13116120 | 0.76 | SMN1; SMN2 (0.44) | POLBALDH1A1ATML3MBTL1SMN1; SMN2 | |
| SCHEMBL2654650 | 0.74 | SMN1; SMN2 (0.47) | POLBALDH1A1L3MBTL1MMP1MMP2 | |
| SCHEMBL17397282 | 0.73 | POLB (0.41) | POLBALDH1A1ATMHTTL3MBTL1 | |
| SCHEMBL6772340 | 0.73 | ALDH1A1 (0.42) | ALDH1A1ATMHTTL3MBTL1HPGD | |
| SCHEMBL27825690 | 0.71 | ALDH1A1 (0.41) | POLBALDH1A1HTTMMP1MMP2 | |
| SCHEMBL967287 | 0.70 | — | — | |
| SCHEMBL15049668 | 0.70 | ALDH1A1 (0.43) | ALDH1A1ATMMAPTHTTMMP1 | |
| SCHEMBL6444830 | 0.70 | SMN1; SMN2 (0.41) | ALDH1A1NPSR1HPGDSMN1; SMN2LMNA | |
| SCHEMBL9851109 | 0.69 | ALDH1A1 (0.48) | POLBALDH1A1ATMHTTMMP1 | |
| Water SCHEMBL7299559 | 0.69 | POLB (0.75) | POLBALDH1A1MAPTNPSR1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016004272-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS LLC (US) | 2016-01-07 | — | — | WO | claimed |
| WO-2016004272-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS LLC (US) | 2016-01-07 | — | — | WO | disclosed |