Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13116120 | 0.76 | SMN1; SMN2 (0.44) | POLBALDH1A1SMN1; SMN2LMNAGAA | |
| SCHEMBL2654650 | 0.74 | SMN1; SMN2 (0.47) | POLBALDH1A1SMN1; SMN2LMNAGAA | |
| SCHEMBL109476 | 0.73 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2LMNAGAANPC1 | |
| SCHEMBL17397276 | 0.73 | POLB (0.41) | POLBALDH1A1SMN1; SMN2LMNAGAA | |
| SCHEMBL27650591 | 0.71 | ALDH1A1 (0.46) | POLBALDH1A1SMN1; SMN2LMNAGAA | |
| SCHEMBL2550524 | 0.71 | ALDH1A1 (0.46) | POLBALDH1A1SMN1; SMN2LMNAGAA | |
| SCHEMBL191289 | 0.71 | ALDH1A1 (0.46) | POLBALDH1A1SMN1; SMN2LMNAGAA | |
| SCHEMBL152231 | 0.71 | ALDH1A1 (0.46) | POLBALDH1A1SMN1; SMN2LMNAGAA | |
| SCHEMBL2558930 | 0.71 | ALDH1A1 (0.46) | POLBALDH1A1SMN1; SMN2LMNAGAA | |
| SCHEMBL8288869 | 0.71 | ALDH1A1 (0.56) | POLBALDH1A1SMN1; SMN2LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016004272-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS LLC (US) | 2016-01-07 | — | — | WO | claimed |
| WO-2016004272-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS LLC (US) | 2016-01-07 | — | — | WO | disclosed |