Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 8/20 | 0.41 |
| ▸ | CDK1 | P06493 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17398044 | 0.91 | TNIK (0.43) | CDK2CDK1 | |
| SCHEMBL17398018 | 0.89 | MAPT (0.44) | CDK2CDK1 | |
| SCHEMBL17398048 | 0.85 | CDK2 (0.41) | CDK2CDK1MEN1KMT2AAKR1B1 | |
| SCHEMBL17398088 | 0.84 | CDK2 (0.53) | CDK2CDK1FLT3 | |
| SCHEMBL17397950 | 0.84 | CDK2 (0.56) | CDK2CDK1FLT3HPGD | |
| SCHEMBL17398080 | 0.83 | NTRK1 (0.40) | CDK2CDK1 | |
| SCHEMBL17397975 | 0.80 | TNIK (0.46) | CDK2CDK1 | |
| SCHEMBL17398060 | 0.77 | AURKA (0.46) | FLT3 | |
| SCHEMBL17398041 | 0.74 | TNIK (0.45) | CDK2CDK1 | |
| SCHEMBL17398011 | 0.74 | HPGD (0.42) | KMT2AFLT3HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016001341-A1 | SULFONYLAMINOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2016-01-07 | — | — | WO | disclosed |