Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 16/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 9/20 | 0.46 |
| ▸ | GSK3B | P49841 | 8/20 | 0.46 |
| ▸ | GSK3A | P49840 | 2/20 | 0.46 |
| ▸ | IGF1R | P08069 | 2/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | PAK4 | O96013 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | LTK | P29376 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17398018 | 0.85 | MAPT (0.44) | PAK4NTRK1 | |
| SCHEMBL17398011 | 0.84 | HPGD (0.42) | AURKAAURKBGSK3BGSK3AIGF1R | |
| SCHEMBL17397979 | 0.82 | JAK2 (0.35) | IGF1RJAK2CDK7JAK3 | |
| SCHEMBL17398037 | 0.80 | IGF1R (0.45) | IGF1R | |
| SCHEMBL17398086 | 0.80 | IGF1R (0.45) | AURKBIGF1RLCK | |
| SCHEMBL17398088 | 0.80 | CDK2 (0.53) | AURKAAURKBPAK4PDGFRBFLT3 | |
| SCHEMBL17397900 | 0.80 | IGF1R (0.39) | IGF1RPAK4 | |
| SCHEMBL17397975 | 0.80 | TNIK (0.46) | — | |
| SCHEMBL17398058 | 0.80 | AURKA (0.49) | AURKAAURKBGSK3BGSK3AIGF1R | |
| SCHEMBL17398061 | 0.79 | LMNA (0.34) | IGF1RPAK4CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016001341-A1 | SULFONYLAMINOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2016-01-07 | — | — | WO | disclosed |