Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | STAT1 | P42224 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 8/20 | 0.43 |
| ▸ | CDK1 | P06493 | 4/20 | 0.43 |
| ▸ | PAK4 | O96013 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | ALPI | P09923 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17398088 | 0.92 | CDK2 (0.53) | MAPTALDH1A1KDM4ELMNAGAA | |
| SCHEMBL17398044 | 0.90 | TNIK (0.43) | MAPTALDH1A1LMNANPC1RAB9A | |
| SCHEMBL17397975 | 0.90 | TNIK (0.46) | MAPTALDH1A1KDM4ELMNAGAA | |
| SCHEMBL17398050 | 0.89 | CDK2 (0.41) | CDK2CDK1 | |
| SCHEMBL17397950 | 0.88 | CDK2 (0.56) | MAPTALDH1A1KDM4EGAACDK2 | |
| SCHEMBL17398080 | 0.87 | NTRK1 (0.40) | MAPTALDH1A1KDM4ELMNAGAA | |
| SCHEMBL17398060 | 0.85 | AURKA (0.46) | PAK4NTRK1 | |
| SCHEMBL17398011 | 0.81 | HPGD (0.42) | MAPTALDH1A1LMNAPAK4NTRK1 | |
| SCHEMBL17398016 | 0.80 | MAPT (0.45) | MAPTALDH1A1KDM4ELMNAGAA | |
| SCHEMBL17398086 | 0.79 | IGF1R (0.45) | CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016001341-A1 | SULFONYLAMINOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2016-01-07 | — | — | WO | disclosed |