SCHEMBL17399388

SCHEMBL17399388

CC1CC2CC[C@H](C1)N2C

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 2/20 0.57
LMNA P02545 1/20 0.57
SLC6A2 P23975 6/20 0.39
SLC6A3 Q01959 6/20 0.39
CHRM1 P11229 7/20 0.36
CHRM3 P20309 4/20 0.36
SLC6A4 P31645 4/20 0.36
DRD3 P35462 4/20 0.36
CHRM2 P08172 3/20 0.36
HRH1 P35367 2/20 0.36
ADRA2A P08913 2/20 0.36
DRD2 P14416 2/20 0.36
ADRA2B P18089 2/20 0.36
ADRA2C P18825 2/20 0.36
HRH2 P25021 2/20 0.36
ADRA1D P25100 2/20 0.36
HTR2A P28223 2/20 0.36
HTR6 P50406 2/20 0.36
SIGMAR1 Q99720 2/20 0.36
CHRM4 P08173 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14424486 1.00 CYP2C9 (0.57) CYP2C9LMNASLC6A2SLC6A3CHRM1
SCHEMBL12463068 1.00 CYP2C9 (0.57) CYP2C9LMNASLC6A2SLC6A3CHRM1
SCHEMBL22631620 1.00 CYP2C9 (0.57) CYP2C9LMNASLC6A2SLC6A3CHRM1
SCHEMBL23100945 1.00 CYP2C9 (0.57) CYP2C9LMNASLC6A2SLC6A3CHRM1
SCHEMBL756764 1.00 CYP2C9 (0.57) CYP2C9LMNASLC6A2SLC6A3CHRM1
SCHEMBL23101821 1.00 CYP2C9 (0.57) CYP2C9LMNASLC6A2SLC6A3CHRM1
SCHEMBL736043 1.00 CYP2C9 (0.57) CYP2C9LMNASLC6A2SLC6A3CHRM1
SCHEMBL13243111 0.88 LMNA (0.46) CYP2C9LMNASLC6A2SLC6A3CHRM1
SCHEMBL16727365 0.88 MAPK1 (0.46) CYP2C9LMNASLC6A2SLC6A3CHRM1
SCHEMBL14310687 0.88 MAPK1 (0.46) CYP2C9LMNASLC6A2SLC6A3CHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3733663-B1 1-[6-[[4-(PHENYLAMINO)-6-QUINAZOLINYL]OXY]-3-AZABICYCLO[3.1.1]HEPT-3-YL]-2-PROPEN-1-ONE DERIVATIVES AND RELATED COMPOUNDS AS IRREVERSIBLE INHIBITORS OF PAN-HER TYROSINE KINASE FOR THE TREATMENT OF CANCER CHENGDU JINRUI FOUND BIOTECH CO LTD (CN) 2023-05-17 EP disclosed
EP-3733663-A1 QUINAZOLINE DERIVATIVE AND USE THEREOF Medshine Discovery Inc. (CN) 2020-11-04 EP disclosed
US-9227971-B2 Pyrazolo[1,5-a]pyrimidine compounds as mTOR inhibitors MERCK SHARP & DOHME CORP. (US) 2016-01-05 US disclosed