Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCKDK | O14874 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | PHOSPHO1 | Q8TCT1 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TLR3 | O15455 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MPI | P34949 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12310725 | 0.77 | BCKDK (0.56) | BCKDKRAB9ASENP1SMN1; SMN2NPC1 | |
| Hydrochloric Acid SCHEMBL16862023 | 0.76 | BCKDK (0.54) | BCKDKRAB9ASENP1SMN1; SMN2NPC1 | |
| SCHEMBL10253780 | 0.73 | BCKDK (0.51) | BCKDKRAB9ASENP1SMN1; SMN2NPC1 | |
| SCHEMBL3738095 | 0.73 | BCKDK (0.55) | BCKDKRAB9ASENP1SMN1; SMN2NPC1 | |
| SCHEMBL3747514 | 0.73 | BCKDK (0.51) | BCKDKRAB9ASENP1SMN1; SMN2NPC1 | |
| SCHEMBL12095386 | 0.73 | BCKDK (0.55) | BCKDKRAB9ASENP1SMN1; SMN2NPC1 | |
| SCHEMBL12263159 | 0.73 | BCKDK (0.51) | BCKDKRAB9ASENP1SMN1; SMN2NPC1 | |
| SCHEMBL594468 | 0.72 | BCKDK (1.00) | BCKDKRAB9ASENP1SMN1; SMN2NPC1 | |
| SCHEMBL2279755 | 0.72 | BCKDK (0.77) | BCKDKRAB9ASENP1SMN1; SMN2NPC1 | |
| SCHEMBL28375936 | 0.71 | LOXL2 (0.53) | RAB9ASMN1; SMN2NPC1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3050882-A1 | PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS | Incyte Holdings Corporation (US) | 2016-08-03 | — | — | EP | disclosed |
| EP-2545045-B1 | PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS | INCYTE HOLDINGS CORP (US) | 2016-01-06 | — | — | EP | disclosed |