⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13990270 | 0.79 | — | — | |
| SCHEMBL12386832 | 0.70 | PTGS2 (0.35) | — | |
| SCHEMBL19296841 | 0.70 | MEN1 (0.33) | — | |
| SCHEMBL21737634 | 0.70 | KDM4E (0.30) | — | |
| SCHEMBL21719935 | 0.70 | — | — | |
| SCHEMBL12431900 | 0.70 | PTGS2 (0.38) | — | |
| SCHEMBL6209643 | 0.68 | MEN1 (0.35) | — | |
| SCHEMBL22711488 | 0.68 | MEN1 (0.32) | — | |
| SCHEMBL20439949 | 0.68 | — | — | |
| SCHEMBL1328328 | 0.67 | MEN1 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11760762-B2 | Thienopyranones and furanopyranones as kinase, bromodomain, and checkpoint inhibitors | SIGNALRX PHARMACEUTICALS, INC. (US) | 2023-09-19 | — | — | US | disclosed |
| EP-3050882-A1 | PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS | Incyte Holdings Corporation (US) | 2016-08-03 | — | — | EP | disclosed |
| EP-2545045-B1 | PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS | INCYTE HOLDINGS CORP (US) | 2016-01-06 | — | — | EP | disclosed |