Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAA50 | Q9GZZ1 | 2/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.38 |
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CPT2 | P23786 | 3/20 | 0.36 |
| ▸ | CPT1A | P50416 | 3/20 | 0.36 |
| ▸ | CPT1B | Q92523 | 2/20 | 0.36 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL174020 | 1.00 | NAA50 (0.38) | NAA50TRPV1CCNCCDK8POLB | |
| SCHEMBL715026 | 0.84 | CPT1A (0.38) | NAA50TRPV1POLBCPT2CPT1A | |
| SCHEMBL166455 | 0.84 | CPT1A (0.38) | NAA50TRPV1POLBCPT2CPT1A | |
| SCHEMBL175219 | 0.82 | HSP90AA1 (0.47) | CCNCCDK8 | |
| SCHEMBL174021 | 0.82 | TRPV1 (0.40) | NAA50TRPV1CCNCCDK8POLB | |
| SCHEMBL164419 | 0.79 | CPT2 (0.50) | NAA50TRPV1POLBCPT2CPT1A | |
| SCHEMBL166687 | 0.79 | CPT2 (0.50) | NAA50TRPV1POLBCPT2CPT1A | |
| SCHEMBL166175 | 0.78 | USP30 (0.38) | TRPV1POLBCPT2CPT1ACPT1B | |
| SCHEMBL716617 | 0.78 | USP30 (0.38) | TRPV1POLBCPT2CPT1ACPT1B | |
| SCHEMBL2725216 | 0.77 | CPT2 (0.38) | NAA50TRPV1POLBCPT2CPT1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611441-A1 | BACE INHIBITORS FOR USE IN THE TREATMENT OF DIABETES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012028563-A1 | BACE INHIBITORS FOR USE IN THE TREATMENT OF DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-03-08 | — | — | WO | disclosed |