SCHEMBL164419

SCHEMBL164419

Cc1csc([C@H]2CCCN2C(=O)c2cccc(C(=O)O)c2)n1

nearest known ligand 0.54

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CPT2 P23786 4/20 0.50
CPT1A P50416 4/20 0.50
ROCK2 O75116 1/20 0.45
TRPV1 Q8NER1 1/20 0.45
CPT1B Q92523 2/20 0.44
POLB P06746 1/20 0.44
NAA50 Q9GZZ1 2/20 0.43
GRM5 P41594 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
L3MBTL3 Q96JM7 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL166687 1.00 CPT2 (0.50) CPT2CPT1AROCK2TRPV1CPT1B
SCHEMBL3511008 0.90 PARP14 (0.45) CPT2CPT1ATRPV1POLBNAA50
SCHEMBL3511003 0.90 PARP14 (0.45) CPT2CPT1ATRPV1POLBNAA50
SCHEMBL165848 0.89 ROCK2 (0.49) CPT2CPT1AROCK2TRPV1CPT1B
SCHEMBL165849 0.89 ROCK2 (0.49) CPT2CPT1AROCK2TRPV1CPT1B
SCHEMBL166997 0.88 TRPV1 (0.43) CPT2CPT1ATRPV1CPT1BPOLB
SCHEMBL166998 0.88 TRPV1 (0.43) CPT2CPT1ATRPV1CPT1BPOLB
SCHEMBL2727219 0.88 CPT1A (0.49) CPT2CPT1ATRPV1CPT1BPOLB
SCHEMBL7872430 0.86 TRPV1 (0.45) CPT2CPT1ATRPV1CPT1BPOLB
SCHEMBL475428 0.86 TRPV1 (0.45) CPT2CPT1ATRPV1CPT1BPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9085571-B2 Nonpeptide HIV-1 protease inhibitors PURDUE RESEARCH FOUNDATION (US) 2015-07-21 US disclosed
US-9085571-B2 Nonpeptide HIV-1 protease inhibitors PURDUE RESEARCH FOUNDATION (US) 2015-07-21 US disclosed
US-20140315946-A1 NONPEPTIDE HIV-1 PROTEASE INHIBITORS PURDUE RESEARCH FOUNDATION 2014-10-23 US disclosed
US-20140315946-A1 NONPEPTIDE HIV-1 PROTEASE INHIBITORS PURDUE RESEARCH FOUNDATION 2014-10-23 US disclosed
US-8791135-B2 Nonpeptide HIV-1 protease inhibitors PURDUE RESEARCH FOUNDATION (US) 2014-07-29 US disclosed
US-8791135-B2 Nonpeptide HIV-1 protease inhibitors PURDUE RESEARCH FOUNDATION (US) 2014-07-29 US disclosed
EP-2611441-A1 BACE INHIBITORS FOR USE IN THE TREATMENT OF DIABETES F.HOFFMANN-LA ROCHE AG (CH) 2013-07-10 EP disclosed
CN-103079562-A BACE inhibitors for use in the treatment of diabetes HOFFMANN LA ROCHE 2013-05-01 CN disclosed
US-20130102593-A1 PYRROLIDINE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF PURDUE RESEARCH FOUNDATION 2013-04-25 US disclosed
US-20130102593-A1 PYRROLIDINE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF PURDUE RESEARCH FOUNDATION 2013-04-25 US disclosed
US-20110178123-A1 NONPEPTIDE HIV-1 PROTEASE INHIBITORS PURDUE RESEARCH FOUNDATION (US) 2011-07-21 US disclosed
WO-2011044057-A1 SULFONAMIDO PYRROLIDINE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF COMENTIS, INC. (US) 2011-04-14 WO disclosed
US-20100286170-A1 (3-HYDROXY-4-AMINO-BUTAN-2-YL) -3- (2-THIAZOL-2-YL-PYRROLIDINE-1-CARBONYL) BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS BETA-SECRETASE INHIBITORS FOR TREATING COMENTIS, INC 2010-11-11 US disclosed
US-20100286170-A1 (3-HYDROXY-4-AMINO-BUTAN-2-YL) -3- (2-THIAZOL-2-YL-PYRROLIDINE-1-CARBONYL) BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS BETA-SECRETASE INHIBITORS FOR TREATING COMENTIS, INC 2010-11-11 US disclosed
US-20100286170-A1 (3-HYDROXY-4-AMINO-BUTAN-2-YL) -3- (2-THIAZOL-2-YL-PYRROLIDINE-1-CARBONYL) BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS BETA-SECRETASE INHIBITORS FOR TREATING COMENTIS, INC 2010-11-11 US disclosed
WO-2010110817-A1 PYRROLIDINE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF COMENTIS, INC. (US) 2010-09-30 WO disclosed
WO-2010042796-A1 COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE PURDUE RESEARCH FOUNDATION (US) 2010-04-15 WO disclosed
WO-2010042892-A1 PYRROLIDINE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF COMENTIS, INC. (US) 2010-04-15 WO disclosed
WO-2010002994-A1 NONPEPTIDE HIV-1 PROTEASE INHIBITORS PURDUE RESEARCH FOUNDATION (US) 2010-01-07 WO disclosed
WO-2009042694-A1 (3-HYDROXY-4-AMINO-BUTAN-2-YL) -3- (2-THIAZOL-2-YL-PYRROLIDINE-1-CARBONYL) BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS BETA-SECRETASE INHIBITORS FOR TREATING COMENTIS, INC. (US) 2009-04-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110178123-A1 NONPEPTIDE HIV-1 PROTEASE INHIBITORS DNPEP, PRSS1, SERPINB1 CPT2 4684/4885CPT1A 3469/4885ROCK2 3079/4885
US-20140315946-A1 NONPEPTIDE HIV-1 PROTEASE INHIBITORS DNPEP, PRSS1, SERPINB1 CPT2 4668/4885CPT1A 3391/4885ROCK2 3090/4885
US-20100286170-A1 (3-HYDROXY-4-AMINO-BUTAN-2-YL) -3- (2-THIAZOL-2-YL-PYRROLIDINE-1-CARBONYL) BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS BETA-SECRETASE INHIBITORS FOR TREATING BACE1, BACE2, PSEN1 CPT2 1089/4885CPT1A 2956/4885ROCK2 2452/4885
US-20130102593-A1 PYRROLIDINE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF BACE1, BACE2, APP CPT2 3164/4885CPT1A 3801/4885ROCK2 3071/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.