SCHEMBL1740246

SCHEMBL1740246

[C]1=CNc2ccccc2N=C1

nearest known ligand 0.33

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
GRK6 P43250 1/20 0.33
NOX1 Q9Y5S8 1/20 0.30
MEN1 O00255 1/20 0.30
USP2 O75604 1/20 0.30
PPARG P37231 1/20 0.30
KMT2A Q03164 1/20 0.30
KEAP1 Q14145 1/20 0.30
NFE2L2 Q16236 1/20 0.30
HSD17B10 Q99714 1/20 0.30
NR2E3 Q9Y5X4 1/20 0.30
NCOR2 Q9Y618 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29280 0.71 MEN1 (0.33) GRK6MEN1USP2PPARGKMT2A
SCHEMBL12809269 0.70 GRK6 (0.31) GRK6
SCHEMBL5082196 0.70 GRK6 (0.31) GRK6
SCHEMBL2903859 0.64 GRK6 (0.34) GRK6MEN1USP2PPARGKMT2A
SCHEMBL9958734 0.64 GRK6 (0.34) GRK6MEN1USP2PPARGKMT2A
SCHEMBL330550 0.64 GRK6 (0.34) GRK6MEN1USP2PPARGKMT2A
SCHEMBL9958738 0.64 GRK6 (0.34) GRK6MEN1USP2PPARGKMT2A
SCHEMBL5466387 0.64 GRK6 (0.42) GRK6MEN1USP2PPARGKMT2A
SCHEMBL27344588 0.62 GRK6 (0.33) GRK6MEN1USP2PPARGKMT2A
Hydrochloric Acid SCHEMBL7477355 0.62 GRK6 (0.33) GRK6MEN1USP2PPARGKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2389366-A1 BENZODIAZEPIN-2-ON DERIVATIVES MSD K.K. (JP) 2011-11-30 EP disclosed
US-8040502-B2 Optical inspection of flat media using direct image technology WDI WISE DEVICE INC. (CA) 2011-10-18 US disclosed
WO-2010084979-A1 BENZODIAZEPIN-2-ON DERIVATIVES BANYU PHARMACEUTICAL CO.,LTD. (JP) 2010-07-29 WO disclosed