Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 14/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL707519 | 0.97 | PARP1 (0.49) | PARP1KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL713960 | 0.97 | PARP1 (0.49) | PARP1KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL709006 | 0.94 | ALOX15 (0.50) | PARP1KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL709498 | 0.94 | ALOX15 (0.50) | PARP1KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL1740264 | 0.90 | PARP1 (0.45) | PARP1KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL1741938 | 0.87 | PARP1 (0.55) | PARP1KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL707047 | 0.87 | PARP1 (0.57) | PARP1KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL708072 | 0.87 | ALOX15 (0.49) | PARP1KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL708071 | 0.87 | ALOX15 (0.49) | PARP1KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL708333 | 0.87 | PARP1 (0.48) | PARP1KDM4EMEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2389379-A1 | Poly (ADP-Ribose) Polymerase (PARP) Inhibitors | Takeda Pharmaceutical Company Limited (JP) | 2011-11-30 | — | — | EP | disclosed |