Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 10/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | TNK1 | Q13470 | 3/20 | 0.38 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.37 |
| ▸ | SMO | Q99835 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL709173 | 0.97 | PARP1 (0.48) | PARP1ALOX15HSD17B10KDM4EMEN1 | |
| SCHEMBL706995 | 0.97 | PARP1 (0.48) | PARP1ALOX15HSD17B10KDM4EMEN1 | |
| SCHEMBL706640 | 0.94 | ALOX15 (0.48) | PARP1ALOX15HSD17B10KDM4EMEN1 | |
| SCHEMBL708323 | 0.94 | ALOX15 (0.48) | PARP1ALOX15HSD17B10KDM4EMEN1 | |
| SCHEMBL1740260 | 0.90 | PARP1 (0.46) | PARP1ALOX15HSD17B10KDM4EMEN1 | |
| SCHEMBL709447 | 0.87 | PARP1 (0.49) | PARP1ALOX15HSD17B10KDM4EMEN1 | |
| SCHEMBL707519 | 0.87 | PARP1 (0.49) | PARP1ALOX15HSD17B10KDM4EMEN1 | |
| SCHEMBL713960 | 0.87 | PARP1 (0.49) | PARP1ALOX15HSD17B10KDM4EMEN1 | |
| SCHEMBL708792 | 0.87 | PARP1 (0.52) | PARP1ALOX15HSD17B10KDM4EMEN1 | |
| SCHEMBL708669 | 0.86 | PARP1 (0.44) | PARP1ALOX15HSD17B10KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2389379-A1 | Poly (ADP-Ribose) Polymerase (PARP) Inhibitors | Takeda Pharmaceutical Company Limited (JP) | 2011-11-30 | — | — | EP | disclosed |