Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FURIN | P09958 | 1/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | SCD | O00767 | 1/20 | 0.34 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.33 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28668608 | 0.85 | FURIN (0.42) | FURINHCRTR2EPHX2RIPK1KDM5A | |
| SCHEMBL1740359 | 0.82 | EPHX2 (0.50) | FURINHCRTR2EPHX2RIPK1KDM5A | |
| SCHEMBL29962133 | 0.82 | GPR119 (0.48) | PDE10A | |
| SCHEMBL27160726 | 0.82 | GPR119 (0.48) | PDE10A | |
| SCHEMBL30729521 | 0.75 | KDM5A (0.58) | HCRTR2EPHX2RIPK1KDM5AHCRTR1 | |
| SCHEMBL5152829 | 0.74 | EPHX2 (0.63) | HCRTR2EPHX2RIPK1KDM5AHCRTR1 | |
| Hydrochloric Acid SCHEMBL23928369 | 0.73 | EPHX2 (0.62) | HCRTR2EPHX2RIPK1KDM5AHCRTR1 | |
| SCHEMBL2146384 | 0.73 | GRIN1 (0.39) | RIPK1L3MBTL1 | |
| SCHEMBL2146654 | 0.71 | CHRNA7 (0.46) | CHRNA7LMNA | |
| SCHEMBL29686345 | 0.70 | GPR119 (0.49) | FURINPDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011088045-A1 | AURORA KINASE COMPOUNDS AND METHODS OF THEIR USE | AMBIT BIOSCIENCES CORPORATION (US) | 2011-07-21 | — | — | WO | disclosed |