Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 2/20 | 0.47 |
| ▸ | SPR | P35270 | 1/20 | 0.47 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | KDM5A | P29375 | 1/20 | 0.45 |
| ▸ | SCD5 | Q86SK9 | 2/20 | 0.45 |
| ▸ | SCD | O00767 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.40 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31228434 | 1.00 | HSD11B1 (0.49) | HSD11B1NAMPTSPRUSP30PDE10A | |
| SCHEMBL2806341 | 0.87 | HSD11B1 (0.60) | HSD11B1NAMPTSPRUSP30KDM5A | |
| SCHEMBL6347014 | 0.86 | HSD11B1 (0.53) | HSD11B1NAMPTSPRUSP30KDM5A | |
| SCHEMBL30327170 | 0.85 | HSD11B1 (0.48) | HSD11B1NAMPTSPRUSP30KDM5A | |
| SCHEMBL18833934 | 0.85 | HSD11B1 (0.48) | HSD11B1NAMPTSPRUSP30KDM5A | |
| SCHEMBL4074303 | 0.83 | HSD11B1 (0.53) | HSD11B1NAMPTSPRUSP30KDM5A | |
| SCHEMBL22059523 | 0.78 | GRIN2B (0.54) | USP30PRMT5WDR77 | |
| SCHEMBL1740546 | 0.78 | PDE10A (0.40) | NAMPTPDE10ASCD5SCDL3MBTL1 | |
| SCHEMBL1739264 | 0.78 | KDM5A (0.46) | PDE10AKDM5ASCD5SCDCHRNB2 | |
| SCHEMBL1740371 | 0.78 | KDM5A (0.46) | HSD11B1PDE10AKDM5ASCD5SCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2389382-A1 | Amino-heterocyclic compounds used as pde9 inhibitors | Pfizer Inc. (US) | 2011-11-30 | — | — | EP | disclosed |
| US-8041687-B2 | Dynamic generation of XML Schema for backend driven data validation | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 2011-10-18 | — | — | US | disclosed |
| WO-2010084438-A1 | AMINO-HETEROCYCLIC COMPOUNDS USED AS PDE9 INHIBITORS | PFIZER INC. (US) | 2010-07-29 | — | — | WO | disclosed |