Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.60 |
| ▸ | SPR | P35270 | 1/20 | 0.58 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.57 |
| ▸ | KDM5A | P29375 | 1/20 | 0.56 |
| ▸ | NAMPT | P43490 | 1/20 | 0.51 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.49 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.49 |
| ▸ | SCD5 | Q86SK9 | 2/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6347014 | 0.93 | HSD11B1 (0.53) | HSD11B1SPRUSP30KDM5ANAMPT | |
| SCHEMBL4074303 | 0.91 | HSD11B1 (0.53) | HSD11B1SPRUSP30KDM5ANAMPT | |
| SCHEMBL1740411 | 0.87 | HSD11B1 (0.49) | HSD11B1SPRUSP30KDM5ANAMPT | |
| SCHEMBL31228434 | 0.87 | HSD11B1 (0.49) | HSD11B1SPRUSP30KDM5ANAMPT | |
| SCHEMBL29640084 | 0.87 | HSD11B1 (0.59) | HSD11B1SPRUSP30KDM5ANAMPT | |
| SCHEMBL19961308 | 0.84 | ALDH1A1 (0.67) | HSD11B1SPRUSP30KDM5ARAB9A | |
| SCHEMBL12791432 | 0.83 | HSD11B1 (0.56) | HSD11B1SPRUSP30KDM5ANAMPT | |
| SCHEMBL19961306 | 0.82 | RAB9A (0.69) | HSD11B1SPRUSP30KDM5ANPC1 | |
| SCHEMBL6042688 | 0.81 | USP30 (0.43) | HSD11B1SPRUSP30KDM5ANAMPT | |
| SCHEMBL16565554 | 0.81 | ACHE (0.56) | HSD11B1SPRNAMPTSCD5EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100240638-A1 | Organic Compounds and their uses | NOVARTIS AG (CH) | 2010-09-23 | — | — | US | disclosed |
| US-7671072-B2 | Aminopyrazole derivatives as GSK-3 inhibitors | PFIZER INC. (US) | 2010-03-02 | — | — | US | disclosed |
| US-20070276010-A1 | Aminopyrazole Derivatives as Gsk-3 Inhibitors | BENBOW JOHN W | 2007-11-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070276010-A1 | Aminopyrazole Derivatives as Gsk-3 Inhibitors | GSK3B, GSK3A, GSKIP | HSD11B1 90/4885SPR 1033/4885USP30 3546/4885 |
| US-20100240638-A1 | Organic Compounds and their uses | OAT, HAVCR2, CYP3A43 | HSD11B1 269/4885SPR 1305/4885USP30 1361/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.