Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Spermine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.56 |
| ▸ | RELA | Q04206 | 4/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | CA12 | O43570 | 2/20 | 0.50 |
| ▸ | F13A1 | P00488 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | CA4 | P22748 | 2/20 | 0.50 |
| ▸ | CA6 | P23280 | 2/20 | 0.50 |
| ▸ | CA5A | P35218 | 2/20 | 0.50 |
| ▸ | THPO | P40225 | 2/20 | 0.50 |
| ▸ | CA7 | P43166 | 2/20 | 0.50 |
| ▸ | CA9 | Q16790 | 2/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.50 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | CASP2 | P42575 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Spermine SCHEMBL27579248 | 1.00 | PAOX (0.56) | PAOXRELATSHRCA12F13A1 | |
| Glycine SCHEMBL27460334 | 0.94 | TSHR (0.52) | PAOXRELATSHRALOX15ALDH1A1 | |
| Glycine SCHEMBL27452821 | 0.92 | TSHR (0.50) | PAOXRELATSHRALOX15ALDH1A1 | |
| Acetic Acid SCHEMBL134140 | 0.90 | PAOX (0.63) | PAOXRELATSHRCA12F13A1 | |
| Dodecanoate SCHEMBL30380627 | 0.89 | PAOX (0.62) | PAOXTSHRALOX15ALDH1A1MEN1 | |
| Hexacosanoic Acid SCHEMBL30380127 | 0.89 | PAOX (0.62) | PAOXTSHRALOX15ALDH1A1MEN1 | |
| Arachidic Acid SCHEMBL30379954 | 0.89 | PAOX (0.62) | PAOXTSHRALOX15ALDH1A1MEN1 | |
| Octanoic Acid SCHEMBL30379986 | 0.89 | PAOX (0.62) | PAOXTSHRALOX15ALDH1A1MEN1 | |
| Stearic Acid SCHEMBL1667358 | 0.89 | PAOX (0.62) | PAOXTSHRALOX15ALDH1A1MEN1 | |
| Adipic Acid SCHEMBL28060751 | 0.89 | PAOX (0.62) | PAOXTSHRALOX15ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023099722-A1 | NANOPARTICLES FOR RELEASE OF NUCLEIC ACIDS | UNIVERSITE CLAUDE BERNARD LYON 1 (FR) | 2023-06-08 | — | — | WO | disclosed |
| US-9572776-B2 | Vectors including an anionic macromolecule and a cationic lipid for delivering small nucleic acids | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2017-02-21 | — | — | US | disclosed |
| US-20120093915-A1 | VECTORS INCLUDING AN ANIONIC MACROMOLECULE AND A CATIONIC LIPID FOR DELIVERING SMALL NUCLEIC ACIDS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) | 2012-04-19 | — | — | US | disclosed |
| EP-2389158-A1 | VECTORS INCLUDING AN ANIONIC MACROMOLECULE AND A CATIONIC LIPID FOR DELIVERING SMALL NUCLEIC ACIDS | Centre National De La Recherche Scientifique CNRS (FR) | 2011-11-30 | — | — | EP | disclosed |
| WO-2010084129-A1 | VECTORS INCLUDING AN ANIONIC MACROMOLECULE AND A CATIONIC LIPID FOR DELIVERING SMALL NUCLEIC ACIDS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2010-07-29 | — | — | WO | disclosed |