SCHEMBL1740438

SCHEMBL1740438

O=C(O)CC[C@H](NC(=O)N[C@@H](Cc1ccc(O)c(I)c1)C(=O)O)C(=O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
FOLH1 Q04609 9/20 1.00
NAALAD2 Q9Y3Q0 5/20 0.68
ALB P02768 7/20 0.53
IL2 P60568 7/20 0.53
RIMKLA Q8IXN7 1/20 0.53
TNF P01375 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4139164 1.00 FOLH1 (1.00) FOLH1NAALAD2ALBIL2RIMKLA
SCHEMBL11941065 0.90 FOLH1 (0.81) FOLH1NAALAD2ALBIL2TNF
SCHEMBL11930754 0.85 FOLH1 (0.74) FOLH1NAALAD2RIMKLA
SCHEMBL13559316 0.84 FOLH1 (0.73) FOLH1NAALAD2
SCHEMBL4317843 0.83 NAALAD2 (0.77) FOLH1NAALAD2RIMKLA
SCHEMBL11936648 0.83 NAALAD2 (0.77) FOLH1NAALAD2RIMKLA
SCHEMBL4317844 0.83 NAALAD2 (0.77) FOLH1NAALAD2RIMKLA
SCHEMBL4132676 0.83 NAALAD2 (0.77) FOLH1NAALAD2RIMKLA
SCHEMBL13515316 0.81 NAALAD2 (1.00) FOLH1NAALAD2RIMKLA
SCHEMBL9965331 0.81 NAALAD2 (1.00) FOLH1NAALAD2RIMKLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230095637-A1 Heterodimers of Glutamic Acid CITIZENS BANK, N.A. 2023-03-30 US disclosed
EP-4023624-A1 HETERODIMERS OF GLUTAMIC ACID Molecular Insight Pharmaceuticals, Inc. (US) 2022-07-06 EP disclosed
EP-3699162-B1 HETERODIMERS OF GLUTAMIC ACID MOLECULAR INSIGHT PHARM INC (US) 2022-06-29 EP disclosed
US-20210246103-A1 HETERODIMERS OF GLUTAMIC ACID CITIZENS BANK, N.A. 2021-08-12 US disclosed
US-20210070695-A1 HETERODIMERS OF GLUTAMIC ACID MOLECULAR INSIGHT PHARMACEUTICALS, INC. 2021-03-11 US disclosed
US-20210070696-A1 HETERODIMERS OF GLUTAMIC ACID MOLECULAR INSIGHT PHARMACEUTICALS, INC. 2021-03-11 US disclosed
EP-3335736-B1 HETERODIMERS OF GLUTAMIC ACID MOLECULAR INSIGHT PHARM INC (US) 2020-12-30 EP disclosed
EP-3699162-A1 HETERODIMERS OF GLUTAMIC ACID Molecular Insight Pharmaceuticals, Inc. (US) 2020-08-26 EP disclosed
US-10647666-B2 Heterodimers of glutamic acid MOLECULAR INSIGHT PHARMACEUTICALS, INC. (US) 2020-05-12 US disclosed
US-10640461-B2 Heterodimers of glutamic acid MOLECULAR INSIGHT PHARMACEUTICALS, INC. (US) 2020-05-05 US disclosed
US-8227634-B2 Imaging agents and methods of imaging NAALADase or PSMA POMPER MARTIN GILBERT (US) 2012-07-24 US disclosed
US-8211401-B2 Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof for inhibiting PSMA MOLECULAR INSIGHT PHARMACEUTICALS, INC. (US) 2012-07-03 US disclosed
EP-2389361-A2 TECHNETIUM- AND RHENIUM-BIS(HETEROARYL) COMPLEXES AND METHODS OF USE THEREOF FOR INHIBITING PSMA Molecular Insight Pharmaceuticals, Inc. (US) 2011-11-30 EP disclosed
US-20100178246-A1 TECHNETIUM- AND RHENIUM-BIS(HETEROARYL) COMPLEXES AND METHODS OF USE THEREOF FOR INHIBITING PSMA MOLECULAR INSIGHT PHARMACEUTICALS, INC. 2010-07-15 US disclosed
WO-2010065902-A2 TECHNETIUM- AND RHENIUM-BIS(HETEROARYL) COMPLEXES AND METHODS OF USE THEREOF FOR INHIBITING PSMA MOLECULAR INSIGHT PHARMACEUTICALS, INC. (US) 2010-06-10 WO disclosed
EP-2097111-A2 HETERODIMERS OF GLUTAMIC ACID Molecular Insight Pharmaceuticals, Inc. (US) 2009-09-09 EP disclosed
US-20090117042-A1 Imaging agents and methods of imaging NAALADase or PSMA THE JOHNS HOPKINS UNIVERSITY (US) 2009-05-07 US disclosed
US-20080193381-A1 HETERODIMERS OF GLUTAMIC ACID MOLECULAR INSIGHT PHARMACEUTICALS, INC. 2008-08-14 US disclosed
US-7408079-B2 Imaging prostate cancer THE JOHNS HOPKINS UNIVERSITY (US) 2008-08-05 US disclosed
WO-2008058192-A2 HETERODIMERS OF GLUTAMIC ACID MOLECULAR INSIGHT PHARMACEUTICALS, INC. (US) 2008-05-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100178246-A1 TECHNETIUM- AND RHENIUM-BIS(HETEROARYL) COMPLEXES AND METHODS OF USE THEREOF FOR INHIBITING PSMA PSMA1, PSMA5, PSMA3 FOLH1 4/4885NAALAD2 339/4885ALB 825/4885
US-20210070695-A1 HETERODIMERS OF GLUTAMIC ACID DDO, GLUL, ASNS FOLH1 5/4885NAALAD2 7/4885ALB 2572/4885
US-20090117042-A1 Imaging agents and methods of imaging NAALADase or PSMA FOLH1, DNPEP, NAALAD2 FOLH1 1/4885NAALAD2 3/4885ALB 1718/4885
US-10647666-B2 Heterodimers of glutamic acid DDO, GLUL, ASNS FOLH1 5/4885NAALAD2 7/4885ALB 2572/4885
US-20080193381-A1 HETERODIMERS OF GLUTAMIC ACID DDO, GLUL, ASNS FOLH1 5/4885NAALAD2 7/4885ALB 2572/4885
US-20210070696-A1 HETERODIMERS OF GLUTAMIC ACID DDO, GLUL, ASNS FOLH1 5/4885NAALAD2 7/4885ALB 2620/4885
US-20230095637-A1 Heterodimers of Glutamic Acid DDO, GLUL, ASNS FOLH1 5/4885NAALAD2 9/4885ALB 2882/4885
US-10640461-B2 Heterodimers of glutamic acid DDO, GLUL, ASNS FOLH1 5/4885NAALAD2 7/4885ALB 2572/4885
US-20210246103-A1 HETERODIMERS OF GLUTAMIC ACID DDO, GLUL, ASNS FOLH1 5/4885NAALAD2 7/4885ALB 2572/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.